Antiphospholipid Syndrome (APS): Thrombosis, Pregnancy, and Treatment | Clinique Omicron<\/title>\n<meta name=\"description\" content=\"Le SAPL est une maladie auto-immune thrombophilique avec anticorps antiphospholipides. Crit\u00e8res de Sapporo, anticoagulation warfarine, pertes f\u0153tales r\u00e9cidivantes et SAPL catastrophique au Qu\u00e9bec.\">\n<meta name=\"keywords\" content=\"syndrome antiphospholipides, SAPL, anticorps antiphospholipides, SAPL thrombose, SAPL grossesse, anticoagulant lupique, anticardiolipine, anti-b\u00eata2GP1, SAPL warfarine, syndrome antiphospholipides Qu\u00e9bec\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Cinzel:wght@600&family=Poppins:wght@400;500;600;700&display=swap\" rel=\"stylesheet\">\n<style>\n@import url('https:\/\/fonts.googleapis.com\/css2?family=Cinzel:wght@600&family=Poppins:wght@400;500;600;700&display=swap');\n\n.co-wrap * {\n font-family: 'Poppins', sans-serif;\n box-sizing: border-box;\n}\n.co-wrap {\n max-width: 1100px;\n margin: 0 auto;\n padding: 30px 0 60px;\n margin-top: 10px;\n}\n.co-label {\n font-family: 'Cinzel', serif;\n font-size: 14px;\n font-weight: bold;\n letter-spacing: 1px;\n text-transform: uppercase;\n color: #4D6577;\n margin-bottom: 14px;\n display: block;\n}\n.co-wrap h1 {\n font-size: 32px;\n font-weight: 500;\n color: #323C52;\n margin: 0 0 22px;\n line-height: 1.2;\n letter-spacing: 0.5px;\n}\n.co-intro {\n font-size: 16px;\n font-weight: 400;\n line-height: 1.75;\n color: #4D6577;\n margin-bottom: 36px;\n padding-bottom: 32px;\n border-bottom: 1px solid rgba(77,101,119,.2);\n}\n.co-wrap h2 {\n font-size: 20px;\n font-weight: 600;\n color: #323C52;\n margin: 32px 0 12px;\n letter-spacing: 0.3px;\n}\n.co-wrap p {\n font-size: 15px;\n font-weight: 400;\n color: #4D6577;\n line-height: 1.7;\n margin-bottom: 14px;\n}\n.co-list {\n list-style: none;\n padding: 0;\n margin: 12px 0 24px;\n}\n.co-list li {\n font-size: 15px;\n font-weight: 400;\n color: #4D6577;\n padding: 10px 14px 10px 38px;\n margin-bottom: 8px;\n border-radius: 6px;\n position: relative;\n background: rgba(77,101,119,.06);\n border-left: 3px solid #4D6577;\n}\n.co-list li::before {\n content: \"\u2713\";\n position: absolute;\n left: 12px;\n font-weight: 700;\n color: #4D6577;\n}\n.co-table {\n width: 100%;\n border-collapse: collapse;\n margin: 14px 0 22px;\n font-size: 14px;\n border-radius: 8px;\n overflow: hidden;\n}\n.co-table thead tr {\n background: #323C52;\n color: #fff;\n}\n.co-table thead th {\n padding: 11px 16px;\n text-align: left;\n font-weight: 600;\n font-size: 13px;\n}\n.co-table tbody tr:nth-child(even) {\n background: rgba(77,101,119,.06);\n}\n.co-table tbody tr:nth-child(odd) {\n background: #fff;\n}\n.co-table td {\n padding: 10px 16px;\n color: #4D6577;\n border-bottom: 1px solid rgba(77,101,119,.12);\n font-size: 14px;\n vertical-align: top;\n}\n.co-table td:first-child {\n font-weight: 600;\n color: #323C52;\n}\n.co-infobox {\n display: flex;\n gap: 12px;\n background: rgba(77,101,119,.06);\n border-radius: 8px;\n border-left: 4px solid #4D6577;\n padding: 14px 18px;\n margin: 18px 0 28px;\n font-size: 14px;\n font-weight: 400;\n color: #4D6577;\n line-height: 1.65;\n}\n.co-infobox .ico {\n font-size: 18px;\n flex-shrink: 0;\n}\n.co-urgence {\n background: #fff8f8;\n border-left: 5px solid #c0392b;\n border-radius: 6px;\n padding: 20px 26px;\n margin: 24px 0 32px;\n}\n.co-urgence .co-urgence-titre {\n font-size: 13px;\n font-weight: 700;\n color: #c0392b;\n letter-spacing: 1.5px;\n text-transform: uppercase;\n margin-bottom: 10px;\n}\n.co-urgence p {\n color: #5a2020;\n font-size: 14px;\n margin: 0 0 10px;\n line-height: 1.7;\n}\n.co-urgence p:last-child {\n margin-bottom: 0;\n}\n.co-disclaimer {\n font-size: 13px;\n color: #8a9aaa;\n font-style: italic;\n border-top: 1px solid rgba(77,101,119,.15);\n padding-top: 24px;\n margin-top: 40px;\n line-height: 1.6;\n}\n<\/style>\n<\/head>\n<body>\n<div class=\"co-wrap\">\n\n <span class=\"co-label\">Rhumatologie & H\u00e9matologie & M\u00e9decine interne<\/span>\n <h1>Antiphospholipid syndrome (APS)<\/h1>\n<style>.oc-fiche-cta{margin:8px 0 34px;padding:22px 24px;border:1.5px solid rgba(50,60,82,.15);border-left:4px solid #FF611C;border-radius:12px;background:#F4F6F8;font-family:Poppins,sans-serif}.oc-fiche-cta-t{font-size:18px;font-weight:600;color:#323C52;margin:0 0 4px;line-height:1.35}.oc-fiche-cta-x{font-size:15px;color:#4D6577;margin:0 0 14px;line-height:1.55}.oc-fiche-cta-b{display:flex;flex-wrap:wrap;gap:10px}.oc-fiche-cta-b a{display:inline-flex;align-items:center;justify-content:center;min-height:44px;padding:10px 18px;border-radius:8px;font-size:14px;font-weight:600;text-decoration:none;box-sizing:border-box}.oc-fiche-cta-b .oc-p{background:#FF611C;color:#fff}.oc-fiche-cta-b .oc-p:hover{background:#E04E0C}.oc-fiche-cta-b .oc-s{background:#fff;color:#323C52;border:1.5px solid rgba(50,60,82,.25)}@media (max-width:600px){.co-wrap h1{font-size:24px;line-height:1.25;text-transform:none}.oc-fiche-cta{padding:18px 16px}.oc-fiche-cta-b a{flex:1 1 100%}body .co-wrap > .co-table,body .co-wrap > .co-table tbody,body .co-wrap > .co-table tr,body .co-wrap > .co-table td{display:block;width:100%;box-sizing:border-box}body .co-wrap > .co-table{min-width:0;table-layout:auto}body .co-wrap > .co-table thead{display:none}body .co-wrap > .co-table tr{margin:0 0 10px;border:1px solid rgba(77,101,119,.18);border-radius:8px;overflow:hidden}body .co-wrap > .co-table td{padding:9px 12px;border:0}body .co-wrap > .co-table td:first-child{font-weight:600;color:#323C52;background:rgba(77,101,119,.07)}#ocw{transform:scale(.8);transform-origin:bottom right}}<\/style><div class=\"oc-fiche-cta\" data-oc-cta=\"fiche-haut-consult\"><p class=\"oc-fiche-cta-t\">Obtenir un avis adapt\u00e9 \u00e0 votre situation<\/p><p class=\"oc-fiche-cta-x\">Consultation en clinique ou en t\u00e9l\u00e9consultation, partout au Qu\u00e9bec.<\/p><div class=\"oc-fiche-cta-b\"><a class=\"oc-p\" href=\"https:\/\/cliniqueomicron.ca\/rendez-vous\/\">Make an appointment<\/a><a class=\"oc-s\" href=\"https:\/\/cliniqueomicron.ca\/consultation-en-ligne\/\">Consult online<\/a><a class=\"oc-s\" href=\"tel:+15146063350\">514 606-3350<\/a><\/div><\/div>\n\n\n <div class=\"co-intro\">\n Le syndrome des antiphospholipides (SAPL) \u2014 d\u00e9sign\u00e9 \u00e9galement syndrome de Hughes (du nom du rhumatologue britannique Graham Hughes qui l'a d\u00e9crit en 1983) \u2014 est une maladie auto-immune thrombophilique acquise caract\u00e9ris\u00e9e par la pr\u00e9sence persistante d'anticorps antiphospholipides (aPL) \u2014 anticoagulant lupique (AL) + anticorps anticardiolipine (aCL) + anticorps anti-b\u00eata2-glycoprot\u00e9ine 1 (anti-\u03b22GP1) \u2014 dirig\u00e9s contre des phospholipides anioniques membranaires ou des prot\u00e9ines de liaison aux phospholipides, entra\u00eenant un \u00e9tat prothrombotique syst\u00e9mique se manifestant par des thromboses veineuses et\/ou art\u00e9rielles r\u00e9cidivantes + et\/ou des complications obst\u00e9tricales sp\u00e9cifiques (pertes f\u0153tales r\u00e9cidivantes + pr\u00e9-\u00e9clampsie s\u00e9v\u00e8re + retard de croissance intra-ut\u00e9rin s\u00e9v\u00e8re + pr\u00e9maturit\u00e9). Le SAPL peut survenir de fa\u00e7on isol\u00e9e (SAPL primaire) ou dans le contexte d'une maladie auto-immune sous-jacente \u2014 principalement le lupus \u00e9ryth\u00e9mateux syst\u00e9mique (LES) dont il complique 30 \u00e0 40 % des cas (SAPL secondaire) \u2014 bien que d'autres connectivites + la polyarthrite rhumato\u00efde + les infections + certains m\u00e9dicaments puissent \u00e9galement induire des aPL transitoires (qui ne constituent pas un SAPL). La physiopathologie repose sur l'activation de l'endoth\u00e9lium vasculaire + des plaquettes + de la voie du compl\u00e9ment + et de la coagulation par les aPL \u2014 particuli\u00e8rement via la liaison des anti-\u03b22GP1 \u00e0 la \u03b22-glycoprot\u00e9ine 1 (prot\u00e9ine anticoagulante naturelle) sur les phospholipides membranaires \u2192 inversion de la protection anticoagulante \u2192 activation de la coagulation + thrombus. La forme catastrophique du SAPL (CAPS \u2014 Catastrophic Antiphospholipid Syndrome) \u2014 heureusement rare (<1 % des SAPL) \u2014 est une urgence m\u00e9dicale mena\u00e7ant le pronostic vital avec des thromboses multiples et simultan\u00e9es touchant au moins 3 organes en moins d'une semaine, entra\u00eenant une d\u00e9faillance multivisc\u00e9rale et une mortalit\u00e9 de 30 \u00e0 50 % m\u00eame avec un traitement maximal.\n <\/div>\n\n <h2>Crit\u00e8res de classification \u2014 Sapporo r\u00e9vis\u00e9s (Sydney 2006)<\/h2>\n <ul class=\"co-list\">\n <li><strong>Le diagnostic de SAPL requiert \u2265 1 crit\u00e8re clinique ET \u2265 1 crit\u00e8re biologique :<\/strong><\/li>\n <li><strong>Crit\u00e8res cliniques :<\/strong> thrombose vasculaire (thrombose veineuse profonde + embolie pulmonaire + AVC + AIT + thrombose art\u00e9rielle p\u00e9riph\u00e9rique + ou thrombose de tout autre vaisseau) + ou morbidit\u00e9 obst\u00e9tricale (\u2265 1 mort f\u0153tale inexpliqu\u00e9e \u2265 10 semaines de grossesse avec morphologie f\u0153tale normale + ou \u2265 3 fausses couches spontan\u00e9es cons\u00e9cutives inexpliqu\u00e9es < 10 SA + ou \u2265 1 naissance pr\u00e9matur\u00e9e < 34 SA secondaire \u00e0 pr\u00e9-\u00e9clampsie s\u00e9v\u00e8re ou insuffisance placentaire s\u00e9v\u00e8re)<\/li>\n <li><strong>Crit\u00e8res biologiques (pr\u00e9sents \u00e0 \u2265 2 reprises \u00e0 \u2265 12 semaines d'intervalle) :<\/strong> anticoagulant lupique (AL) positif + ou aCL IgG ou IgM \u2265 40 GPL\/MPL (ou > 99e percentile) + ou anti-\u03b22GP1 IgG ou IgM > 99e percentile + la persistance sur 2 mesures \u00e0 12 semaines d'intervalle est obligatoire pour \u00e9viter de diagnostiquer des aPL transitoires (infections + m\u00e9dicaments) qui ne constituent pas un vrai SAPL<\/li>\n <li><strong>Profil \u00e0 risque \u00e9lev\u00e9 (triple positivit\u00e9) :<\/strong> Positivity of all 3 tests (lupus anticoagulant + anticardiolipin antibodies + anti-beta-2 glycoprotein 1 antibodies) = highest thrombotic risk + high risk of recurrence \u2192 lifelong anticoagulation often recommended<\/li>\n <\/ul>\n\n <h2>Clinical manifestations<\/h2>\n <ul class=\"co-list\">\n <li><strong>Venous thrombosis<\/strong> Deep vein thrombosis of the lower extremities ++ pulmonary embolism cerebral venous sinus thrombosis hepatic vein thrombosis (Budd-Chiari syndrome) renal vein thrombosis retinal vein thrombosis<\/li>\n <li><strong>Thromboses art\u00e9rielles :<\/strong> AVC isch\u00e9mique (particuli\u00e8rement chez la femme jeune < 50 ans sans facteur de risque classique \u2192 \u00e9voquer le SAPL) + AIT + infarctus du myocarde (chez le jeune) + occlusion art\u00e9rielle des membres + thrombose art\u00e9rielle r\u00e9tinienne (amaurose fugace + OAVR)<\/li>\n <li><strong>Manifestations obst\u00e9tricales :<\/strong> pertes f\u0153tales r\u00e9cidivantes (fausses couches spontan\u00e9es r\u00e9cidivantes + mort f\u0153tale in utero tardive) + pr\u00e9-\u00e9clampsie s\u00e9v\u00e8re pr\u00e9coce (< 34 SA) + syndrome HELLP + retard de croissance intra-ut\u00e9rin s\u00e9v\u00e8re + par m\u00e9canisme de thrombose des vaisseaux placentaires<\/li>\n <li><strong>Manifestations non crit\u00e8res (SAPL \u00e9volu\u00e9) :<\/strong> thrombocytopenia (20\u201350 % \u2014 platelets 50,000\u2013150,000\/\u00b5L) + valvular lesions (Libman-Sacks vegetations + valvular thickening + mitral or aortic insufficiency) + livedo reticularis (purplish skin network) + antiphospholipid nephropathy (renal thrombotic microangiopathy) + leg skin ulcers + refractory migraine<\/li>\n <\/ul>\n\n <h2>Catastrophic SAPL (CAPS)<\/h2>\n <ul class=\"co-list\">\n <li><strong>Definition:<\/strong> Multiple thromboses affecting three or more organs or vascular territories developing simultaneously or within less than a week, plus histology showing small vessel occlusions (thrombotic microangiopathy) and confirmed antiphospholipid antibodies.<\/li>\n <li><strong>Facteurs d\u00e9clenchants :<\/strong> infection bact\u00e9rienne (trigger le plus fr\u00e9quent \u2014 20 % des CAPS) + chirurgie + arr\u00eat brutal de l'anticoagulation + m\u00e9dicaments + grossesse<\/li>\n <li><strong>Manifestations:<\/strong> kidney failure (78 %) + lung damage (ARDS + 66 %) + brain damage (56 %) + heart damage (50 %) + severe thrombocytopenia + DIC + skin signs (livedo + necrosis)<\/li>\n <li><strong>Traitement (triple th\u00e9rapie) :<\/strong> IV anticoagulation (unfractionated heparin) + high-dose systemic corticosteroids (methylprednisolone 1 g\/day \u00d7 3 days then prednisone 1\u20132 mg\/kg\/day) + plasma exchange and\/or IV immunoglobulins \u2192 rituximab + eculizumab if refractory + 30\u201350% mortality % even with optimal treatment<\/li>\n <\/ul>\n\n <h2>Traitement \u2014 anticoagulation<\/h2>\n\n <table class=\"co-table\">\n <thead>\n <tr>\n <th>Situation<\/th>\n <th>Recommended treatment<\/th>\n <th>Dur\u00e9e et cibles<\/th>\n <\/tr>\n <\/thead>\n <tbody>\n <tr>\n <td>Premier \u00e9pisode thrombotique veineux + aPL confirm\u00e9<\/td>\n <td>Warfarine (Coumadin\u00ae) avec chevauchement h\u00e9parine jusqu'\u00e0 INR th\u00e9rapeutique + INR cible 2,0\u20133,0<\/td>\n <td>Anticoagulation \u00e0 vie si aPL persistants (les directives recommandent g\u00e9n\u00e9ralement l'anticoagulation \u00e0 vie apr\u00e8s le premier \u00e9pisode dans le contexte d'un SAPL confirm\u00e9) + profil triple positif \u2192 dur\u00e9e \u00e0 vie obligatoire<\/td>\n <\/tr>\n <tr>\n <td>Premier \u00e9pisode thrombotique art\u00e9riel (AVC + IDM)<\/td>\n <td>Warfarine INR cible 2,0\u20133,0 + ou INR 3,0\u20134,0 selon le profil aPL + aspirin 81\u2013100 mg\/j en combinaison (selon les lignes directrices)<\/td>\n <td>Anticoagulation \u00e0 vie + gestion rigoureuse des facteurs de risque cardiovasculaires (TA + lipides + tabac + diab\u00e8te)<\/td>\n <\/tr>\n <tr>\n <td>SAPL obst\u00e9trical (sans thrombose ant\u00e9rieure)<\/td>\n <td>H\u00e9parine de bas poids mol\u00e9culaire (HBPM \u2014 \u00e9noxaparine dose prophylactique 40 mg\/j SC) + aspirine faible dose (81 mg\/j) d\u00e8s la conception jusqu'\u00e0 l'accouchement + poursuite de l'HBPM 6 semaines post-partum<\/td>\n <td>Taux de naissances vivantes : 70\u201380 % sous traitement combin\u00e9 vs < 25 % sans traitement + HBPM \u00e0 dose th\u00e9rapeutique si ant\u00e9c\u00e9dent thrombotique associ\u00e9<\/td>\n <\/tr>\n <tr>\n <td>aPL positifs SANS crit\u00e8res cliniques (aPL asymptomatiques)<\/td>\n <td>Aspirine 81 mg\/j (prophylaxie primaire \u2014 controverse) + ou surveillance seule si profil aPL \u00e0 faible risque (aCL IgM isol\u00e9 \u00e0 faible titre) + hydroxychloroquine (lupus sous-jacent) \u2192 r\u00e9duit le risque de premi\u00e8re thrombose<\/td>\n <td>Facteurs de risque additionnels \u2192 aspirin + ou hydroxychloroquine + contr\u00f4le agressif des facteurs de risque cardiovasculaires classiques<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n\n <div class=\"co-infobox\">\n <span class=\"ico\">\u2119\ufe0f<\/span>\n <span>Les anticoagulants oraux directs (AOD \u2014 rivaroxaban + apixaban + dabigatran) ne sont PAS recommand\u00e9s dans le SAPL avec triple positivit\u00e9 ou ant\u00e9c\u00e9dent thrombotique art\u00e9riel \u2014 l'essai TRAPS (rivaroxaban vs warfarine dans le SAPL \u00e0 haut risque) a \u00e9t\u00e9 arr\u00eat\u00e9 pr\u00e9matur\u00e9ment en raison d'un taux de r\u00e9cidive thrombotique significativement plus \u00e9lev\u00e9 sous rivaroxaban. La warfarine reste le traitement de r\u00e9f\u00e9rence du SAPL thrombotique. Les AOD peuvent \u00eatre envisag\u00e9s uniquement dans les profils \u00e0 faible risque (aCL isol\u00e9 \u00e0 titre faible + premier \u00e9pisode veineux simple) en attendant des donn\u00e9es suppl\u00e9mentaires.<\/span>\n <\/div>\n\n <h2>SAPL et lupus \u2014 association importante<\/h2>\n <ul class=\"co-list\">\n <li><strong>Pr\u00e9valence :<\/strong> 30-40% of lupus patients have aPL+ and 50-70% of patients with secondary APS have lupus+ systematically screen for aPL in all lupus patients<\/li>\n <li><strong>Hydroxychloroquine (Plaquenil\u00ae) :<\/strong> Reduces the risk of thrombosis in lupus patients with aPL + mechanism: inhibition of platelet activation by aPL + anti-aggregating properties + immunomodulatory action \u2192 recommended for all lupus patients with positive aPL<\/li>\n <li><strong>Lupus pregnancy + APS:<\/strong> Highly specialized care at a reference center + LMWH + aspirin + hydroxychloroquine (safe in pregnancy) + prednisone if active lupus + close obstetric monitoring (bi-monthly placental Doppler ultrasound + fetal monitoring)<\/li>\n <\/ul>\n\n <div class=\"co-urgence\">\n <div class=\"co-urgence-titre\">Urgent medical consultation<\/div>\n <p>Consulter aux urgences imm\u00e9diatement si une personne connue pour SAPL pr\u00e9sente des signes de thrombose (douleur + gonflement d'un membre + dyspn\u00e9e + douleur thoracique + d\u00e9ficit neurologique) + ou si plusieurs organes semblent touch\u00e9s simultan\u00e9ment (confusion + oligurie + dyspn\u00e9e + douleur abdominale en m\u00eame temps) \u2014 ce dernier tableau peut \u00e9voquer un SAPL catastrophique, urgence m\u00e9dicale avec mortalit\u00e9 de 30\u201350 %. Pour le bilan initial des aPL (anticoagulant lupique + aCL + anti-\u03b22GP1) et l'orientation vers la rhumatologie ou l'h\u00e9matologie, Clinique Omicron offre des consultations dans ses points de service au Qu\u00e9bec et en t\u00e9l\u00e9m\u00e9decine. Pour prendre rendez-vous, visitez <a href=\"https:\/\/cliniqueomicron.ca\" style=\"color:#c0392b;font-weight:600;text-decoration:none;\">cliniqueomicron.ca<\/a>.<\/p>\n <\/div>\n\n <h2>Consult at Clinique Omicron<\/h2>\n <p>Les m\u00e9decins et infirmiers praticiens sp\u00e9cialis\u00e9s (IPS) de Clinique Omicron d\u00e9pistent le SAPL chez les patients pr\u00e9sentant des thromboses r\u00e9cidivantes inexpliqu\u00e9es + des fausses couches r\u00e9cidivantes + ou un AVC chez la femme jeune, prescrivent le bilan aPL complet (AL + aCL + anti-\u03b22GP1) avec r\u00e9p\u00e9tition \u00e0 12 semaines pour confirmer la persistance, initient l'aspirine en prophylaxie primaire et la warfarine en traitement des thromboses confirm\u00e9es, assurent le suivi de l'INR sous warfarine, orientent vers la rhumatologie pour le SAPL secondaire au lupus et vers l'obst\u00e9trique sp\u00e9cialis\u00e9e pour les grossesses \u00e0 risque. Des consultations sont disponibles dans plusieurs points de service au Qu\u00e9bec et en t\u00e9l\u00e9m\u00e9decine. Pour prendre rendez-vous, visitez <a href=\"https:\/\/cliniqueomicron.ca\" style=\"color:#4D6577;font-weight:600;text-decoration:none;\">cliniqueomicron.ca<\/a>.<\/p>\n\n <p class=\"co-disclaimer\">Le contenu de cette page est fourni \u00e0 titre informatif uniquement et ne remplace pas l'avis d'un m\u00e9decin, d'un rhumatologue ou d'un h\u00e9matologue. Le SAPL est une maladie complexe n\u00e9cessitant une anticoagulation \u00e0 long terme dont l'arr\u00eat brutal peut d\u00e9clencher un SAPL catastrophique. Les anticoagulants oraux directs (AOD) ne sont PAS recommand\u00e9s en premi\u00e8re intention dans le SAPL thrombotique \u2014 la warfarine reste le standard de soins.<\/p>\n\n<\/div>\n<\/body>\n<\/html>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron Rhumatologie & H\u00e9matologie & M\u00e9decine interne Syndrome des antiphospholipides (SAPL) Le syndrome des antiphospholipides (SAPL) \u2014 d\u00e9sign\u00e9 \u00e9galement syndrome de Hughes (du nom du rhumatologue britannique Graham Hughes qui l’a d\u00e9crit en 1983) \u2014 est une maladie auto-immune thrombophilique acquise caract\u00e9ris\u00e9e par la… <a href=\"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/\" rel=\"bookmark\">Read More \"<span class=\"screen-reader-text\">Antiphospholipid Syndrome (APS): Thrombosis, Pregnancy, and Treatment | Clinique Omicron<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_metasync_otto_title":"Syndrome des antiphospholipides | Brossard | Clinique Omicron","_metasync_otto_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","_metasync_otto_keywords":"","_metasync_otto_og_title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","_metasync_otto_og_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","_metasync_otto_twitter_title":"Syndrome Antiphospholipides | Clinique Omicron","_metasync_otto_twitter_description":"","rank_math_title":"","rank_math_description":"","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_aioseo_title":"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron","_aioseo_description":"Le SAPL est une thrombophilie auto-immune avec anticorps antiphospholipides. Crit\u00e8res Sapporo Sydney AL aCL anti-\u03b22GP1 persistance 12 semaines, warfarine INR 2-3 AOD contre-indiqu\u00e9s, HBPM aspirin grossesse, CAPS catastrophique au Qu\u00e9bec.","_metasync_seo_title":"Syndrome des antiphospholipides | Clinique Omicron","_metasync_seo_desc":"","_metasync_breadcrumb_title":"","_metasync_primary_category":0,"_metasync_primary_product_cat":0,"_metasync_imported_seo_title":"","_metasync_imported_seo_desc":"","_metasync_otto_disabled":"","_metasync_hreflang":"","_metasync_plugin_sync_ts":"{\"aioseo\":\"2026-09-03T07:54:20+00:00\"}","_metasync_robots_advanced":"","_metasync_og_title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","_metasync_og_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","_metasync_twitter_title":"Syndrome Antiphospholipides | Clinique Omicron","_metasync_twitter_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","footnotes":""},"class_list":["post-24978","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t<meta name=\"description\" content=\"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....\" \/>\n\t<meta name=\"robots\" content=\"max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n\t<meta name=\"google-site-verification\" content=\"yYDMZv-nme7Cg-KrW5GmEWceBTrCDv8zhSkkXdJSnyM\" \/>\n\t<meta name=\"msvalidate.01\" content=\"3225E6935FC4F40C7DDCE56C37141BA8\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinique Omicron - Clinique M\u00e9dicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec\" \/>\n\t\t<meta property=\"og:description\" content=\"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2026-03-01T02:54:43+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2026-09-14T23:52:47+00:00\" \/>\n\t\t<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/cliniqueomicron\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:site\" content=\"@CliniqueOmicron\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....\" \/>\n\t\t<meta name=\"twitter:creator\" content=\"@CliniqueOmicron\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en#listItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#listItem\",\"name\":\"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#listItem\",\"position\":2,\"name\":\"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en#listItem\",\"name\":\"Accueil\"}}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#webpage\",\"url\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/\",\"name\":\"Syndrome des antiphospholipides | Clinique Omicron\",\"description\":\"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\\u00e9dicale qui peut n\\u00e9cessiter une \\u00e9valuation et un suivi m\\u00e9dical appropri\\u00e9s....\",\"inLanguage\":\"en-CA\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#breadcrumblist\"},\"datePublished\":\"2026-02-28T22:54:43-04:00\",\"dateModified\":\"2026-09-14T19:52:47-04:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/\",\"name\":\"Clinique Omicron\",\"description\":\"Clinique M\\u00e9dicale\",\"inLanguage\":\"en-CA\",\"publisher\":{\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t\r\n\t\t<title>Syndrome des antiphospholipides | Clinique Omicron<\/title>\n\n","aioseo_head_json":{"title":"Syndrome des antiphospholipides | Clinique Omicron","description":"Antiphospholipid Syndrome Antiphospholipid Syndrome is a medical condition that may require appropriate medical evaluation and monitoring....","canonical_url":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/","robots":"max-snippet:-1, max-image-preview:large, max-video-preview:-1","keywords":"","webmasterTools":{"google-site-verification":"yYDMZv-nme7Cg-KrW5GmEWceBTrCDv8zhSkkXdJSnyM","msvalidate.01":"3225E6935FC4F40C7DDCE56C37141BA8","miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BreadcrumbList","@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/cliniqueomicron.ca\/en#listItem","position":1,"name":"Accueil","item":"https:\/\/cliniqueomicron.ca\/en","nextItem":{"@type":"ListItem","@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#listItem","name":"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron"}},{"@type":"ListItem","@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#listItem","position":2,"name":"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron","previousItem":{"@type":"ListItem","@id":"https:\/\/cliniqueomicron.ca\/en#listItem","name":"Accueil"}}]},{"@type":"WebPage","@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#webpage","url":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/","name":"Syndrome des antiphospholipides | Clinique Omicron","description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","inLanguage":"en-CA","isPartOf":{"@id":"https:\/\/cliniqueomicron.ca\/en\/#website"},"breadcrumb":{"@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#breadcrumblist"},"datePublished":"2026-02-28T22:54:43-04:00","dateModified":"2026-09-14T19:52:47-04:00"},{"@type":"WebSite","@id":"https:\/\/cliniqueomicron.ca\/en\/#website","url":"https:\/\/cliniqueomicron.ca\/en\/","name":"Clinique Omicron","description":"Clinique M\u00e9dicale","inLanguage":"en-CA","publisher":{"@id":"https:\/\/cliniqueomicron.ca\/en\/#organization"}}]},"og:locale":"en_US","og:site_name":"Clinique Omicron - Clinique M\u00e9dicale","og:type":"article","og:title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","og:description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","og:url":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/","og:image":"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg","og:image:secure_url":"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg","article:published_time":"2026-03-01T02:54:43+00:00","article:modified_time":"2026-09-14T23:52:47+00:00","article:publisher":"https:\/\/www.facebook.com\/cliniqueomicron","twitter:card":"summary_large_image","twitter:site":"@CliniqueOmicron","twitter:title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","twitter:description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","twitter:creator":"@CliniqueOmicron","twitter:image":"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg"},"aioseo_meta_data":{"post_id":"24978","title":"Syndrome des antiphospholipides | Clinique Omicron","description":"Antiphospholipid Syndrome Antiphospholipid Syndrome is a medical condition that may require appropriate medical evaluation and monitoring....","keywords":null,"keyphrases":{"focus":{"keyphrase":"antiphospholipides","score":75,"analysis":{"keyphraseInTitle":{"score":9,"maxScore":9,"error":0},"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":1},"keyphraseInURL":{"score":5,"maxScore":5,"error":0},"keyphraseInIntroduction":{"score":9,"maxScore":9,"error":0},"keyphraseInSubHeadings":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":[],"keywordDensity":{"type":"high","score":0,"maxScore":9,"error":1}}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","og_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":true,"twitter_card":"summary_large_image","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":"Syndrome Antiphospholipides | Clinique Omicron","twitter_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"WebPage","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":false,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"large","priority":null,"frequency":"default","local_seo":null,"seo_analyzer_scan_date":"2026-09-15 00:05:17","breadcrumb_settings":null,"limit_modified_date":false,"reviewed_by":null,"open_ai":null,"ai":{"faqs":[],"keyPoints":[],"titles":[],"descriptions":[],"socialPosts":{"email":[],"linkedin":[],"twitter":[],"facebook":[],"instagram":[]}},"created":"2026-03-01 04:10:15","updated":"2026-09-15 00:22:17","focus_keyword":"antiphospholipides","additional_keywords":null,"truseo_locale":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t<a href=\"https:\/\/cliniqueomicron.ca\/en\" title=\"Accueil\">Accueil<\/a>\n<\/span><span class=\"aioseo-breadcrumb-separator\">\u203a<\/span><span class=\"aioseo-breadcrumb\">\n\tSyndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron\n<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Accueil","link":"https:\/\/cliniqueomicron.ca\/en"},{"label":"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron","link":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/"}],"_links":{"self":[{"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/pages\/24978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/comments?post=24978"}],"version-history":[{"count":4,"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/pages\/24978\/revisions"}],"predecessor-version":[{"id":31836,"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/pages\/24978\/revisions\/31836"}],"wp:attachment":[{"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/media?parent=24978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

\n\t\t\t\t

\n\t\t\t\t\t

\n\t\t\t\t

\n\t\t\t\t\t\n\n\n\n\nAntiphospholipid Syndrome (APS): Thrombosis, Pregnancy, and Treatment | Clinique Omicron<\/title>\n<meta name=\"description\" content=\"Le SAPL est une maladie auto-immune thrombophilique avec anticorps antiphospholipides. Crit\u00e8res de Sapporo, anticoagulation warfarine, pertes f\u0153tales r\u00e9cidivantes et SAPL catastrophique au Qu\u00e9bec.\">\n<meta name=\"keywords\" content=\"syndrome antiphospholipides, SAPL, anticorps antiphospholipides, SAPL thrombose, SAPL grossesse, anticoagulant lupique, anticardiolipine, anti-b\u00eata2GP1, SAPL warfarine, syndrome antiphospholipides Qu\u00e9bec\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Cinzel:wght@600&family=Poppins:wght@400;500;600;700&display=swap\" rel=\"stylesheet\">\n<style>\n@import url('https:\/\/fonts.googleapis.com\/css2?family=Cinzel:wght@600&family=Poppins:wght@400;500;600;700&display=swap');\n\n.co-wrap * {\n font-family: 'Poppins', sans-serif;\n box-sizing: border-box;\n}\n.co-wrap {\n max-width: 1100px;\n margin: 0 auto;\n padding: 30px 0 60px;\n margin-top: 10px;\n}\n.co-label {\n font-family: 'Cinzel', serif;\n font-size: 14px;\n font-weight: bold;\n letter-spacing: 1px;\n text-transform: uppercase;\n color: #4D6577;\n margin-bottom: 14px;\n display: block;\n}\n.co-wrap h1 {\n font-size: 32px;\n font-weight: 500;\n color: #323C52;\n margin: 0 0 22px;\n line-height: 1.2;\n letter-spacing: 0.5px;\n}\n.co-intro {\n font-size: 16px;\n font-weight: 400;\n line-height: 1.75;\n color: #4D6577;\n margin-bottom: 36px;\n padding-bottom: 32px;\n border-bottom: 1px solid rgba(77,101,119,.2);\n}\n.co-wrap h2 {\n font-size: 20px;\n font-weight: 600;\n color: #323C52;\n margin: 32px 0 12px;\n letter-spacing: 0.3px;\n}\n.co-wrap p {\n font-size: 15px;\n font-weight: 400;\n color: #4D6577;\n line-height: 1.7;\n margin-bottom: 14px;\n}\n.co-list {\n list-style: none;\n padding: 0;\n margin: 12px 0 24px;\n}\n.co-list li {\n font-size: 15px;\n font-weight: 400;\n color: #4D6577;\n padding: 10px 14px 10px 38px;\n margin-bottom: 8px;\n border-radius: 6px;\n position: relative;\n background: rgba(77,101,119,.06);\n border-left: 3px solid #4D6577;\n}\n.co-list li::before {\n content: \"\u2713\";\n position: absolute;\n left: 12px;\n font-weight: 700;\n color: #4D6577;\n}\n.co-table {\n width: 100%;\n border-collapse: collapse;\n margin: 14px 0 22px;\n font-size: 14px;\n border-radius: 8px;\n overflow: hidden;\n}\n.co-table thead tr {\n background: #323C52;\n color: #fff;\n}\n.co-table thead th {\n padding: 11px 16px;\n text-align: left;\n font-weight: 600;\n font-size: 13px;\n}\n.co-table tbody tr:nth-child(even) {\n background: rgba(77,101,119,.06);\n}\n.co-table tbody tr:nth-child(odd) {\n background: #fff;\n}\n.co-table td {\n padding: 10px 16px;\n color: #4D6577;\n border-bottom: 1px solid rgba(77,101,119,.12);\n font-size: 14px;\n vertical-align: top;\n}\n.co-table td:first-child {\n font-weight: 600;\n color: #323C52;\n}\n.co-infobox {\n display: flex;\n gap: 12px;\n background: rgba(77,101,119,.06);\n border-radius: 8px;\n border-left: 4px solid #4D6577;\n padding: 14px 18px;\n margin: 18px 0 28px;\n font-size: 14px;\n font-weight: 400;\n color: #4D6577;\n line-height: 1.65;\n}\n.co-infobox .ico {\n font-size: 18px;\n flex-shrink: 0;\n}\n.co-urgence {\n background: #fff8f8;\n border-left: 5px solid #c0392b;\n border-radius: 6px;\n padding: 20px 26px;\n margin: 24px 0 32px;\n}\n.co-urgence .co-urgence-titre {\n font-size: 13px;\n font-weight: 700;\n color: #c0392b;\n letter-spacing: 1.5px;\n text-transform: uppercase;\n margin-bottom: 10px;\n}\n.co-urgence p {\n color: #5a2020;\n font-size: 14px;\n margin: 0 0 10px;\n line-height: 1.7;\n}\n.co-urgence p:last-child {\n margin-bottom: 0;\n}\n.co-disclaimer {\n font-size: 13px;\n color: #8a9aaa;\n font-style: italic;\n border-top: 1px solid rgba(77,101,119,.15);\n padding-top: 24px;\n margin-top: 40px;\n line-height: 1.6;\n}\n<\/style>\n<\/head>\n<body>\n<div class=\"co-wrap\">\n\n <span class=\"co-label\">Rhumatologie & H\u00e9matologie & M\u00e9decine interne<\/span>\n <h1>Antiphospholipid syndrome (APS)<\/h1>\n<style>.oc-fiche-cta{margin:8px 0 34px;padding:22px 24px;border:1.5px solid rgba(50,60,82,.15);border-left:4px solid #FF611C;border-radius:12px;background:#F4F6F8;font-family:Poppins,sans-serif}.oc-fiche-cta-t{font-size:18px;font-weight:600;color:#323C52;margin:0 0 4px;line-height:1.35}.oc-fiche-cta-x{font-size:15px;color:#4D6577;margin:0 0 14px;line-height:1.55}.oc-fiche-cta-b{display:flex;flex-wrap:wrap;gap:10px}.oc-fiche-cta-b a{display:inline-flex;align-items:center;justify-content:center;min-height:44px;padding:10px 18px;border-radius:8px;font-size:14px;font-weight:600;text-decoration:none;box-sizing:border-box}.oc-fiche-cta-b .oc-p{background:#FF611C;color:#fff}.oc-fiche-cta-b .oc-p:hover{background:#E04E0C}.oc-fiche-cta-b .oc-s{background:#fff;color:#323C52;border:1.5px solid rgba(50,60,82,.25)}@media (max-width:600px){.co-wrap h1{font-size:24px;line-height:1.25;text-transform:none}.oc-fiche-cta{padding:18px 16px}.oc-fiche-cta-b a{flex:1 1 100%}body .co-wrap > .co-table,body .co-wrap > .co-table tbody,body .co-wrap > .co-table tr,body .co-wrap > .co-table td{display:block;width:100%;box-sizing:border-box}body .co-wrap > .co-table{min-width:0;table-layout:auto}body .co-wrap > .co-table thead{display:none}body .co-wrap > .co-table tr{margin:0 0 10px;border:1px solid rgba(77,101,119,.18);border-radius:8px;overflow:hidden}body .co-wrap > .co-table td{padding:9px 12px;border:0}body .co-wrap > .co-table td:first-child{font-weight:600;color:#323C52;background:rgba(77,101,119,.07)}#ocw{transform:scale(.8);transform-origin:bottom right}}<\/style><div class=\"oc-fiche-cta\" data-oc-cta=\"fiche-haut-consult\"><p class=\"oc-fiche-cta-t\">Obtenir un avis adapt\u00e9 \u00e0 votre situation<\/p><p class=\"oc-fiche-cta-x\">Consultation en clinique ou en t\u00e9l\u00e9consultation, partout au Qu\u00e9bec.<\/p><div class=\"oc-fiche-cta-b\"><a class=\"oc-p\" href=\"https:\/\/cliniqueomicron.ca\/rendez-vous\/\">Make an appointment<\/a><a class=\"oc-s\" href=\"https:\/\/cliniqueomicron.ca\/consultation-en-ligne\/\">Consult online<\/a><a class=\"oc-s\" href=\"tel:+15146063350\">514 606-3350<\/a><\/div><\/div>\n\n\n <div class=\"co-intro\">\n Le syndrome des antiphospholipides (SAPL) \u2014 d\u00e9sign\u00e9 \u00e9galement syndrome de Hughes (du nom du rhumatologue britannique Graham Hughes qui l'a d\u00e9crit en 1983) \u2014 est une maladie auto-immune thrombophilique acquise caract\u00e9ris\u00e9e par la pr\u00e9sence persistante d'anticorps antiphospholipides (aPL) \u2014 anticoagulant lupique (AL) + anticorps anticardiolipine (aCL) + anticorps anti-b\u00eata2-glycoprot\u00e9ine 1 (anti-\u03b22GP1) \u2014 dirig\u00e9s contre des phospholipides anioniques membranaires ou des prot\u00e9ines de liaison aux phospholipides, entra\u00eenant un \u00e9tat prothrombotique syst\u00e9mique se manifestant par des thromboses veineuses et\/ou art\u00e9rielles r\u00e9cidivantes + et\/ou des complications obst\u00e9tricales sp\u00e9cifiques (pertes f\u0153tales r\u00e9cidivantes + pr\u00e9-\u00e9clampsie s\u00e9v\u00e8re + retard de croissance intra-ut\u00e9rin s\u00e9v\u00e8re + pr\u00e9maturit\u00e9). Le SAPL peut survenir de fa\u00e7on isol\u00e9e (SAPL primaire) ou dans le contexte d'une maladie auto-immune sous-jacente \u2014 principalement le lupus \u00e9ryth\u00e9mateux syst\u00e9mique (LES) dont il complique 30 \u00e0 40 % des cas (SAPL secondaire) \u2014 bien que d'autres connectivites + la polyarthrite rhumato\u00efde + les infections + certains m\u00e9dicaments puissent \u00e9galement induire des aPL transitoires (qui ne constituent pas un SAPL). La physiopathologie repose sur l'activation de l'endoth\u00e9lium vasculaire + des plaquettes + de la voie du compl\u00e9ment + et de la coagulation par les aPL \u2014 particuli\u00e8rement via la liaison des anti-\u03b22GP1 \u00e0 la \u03b22-glycoprot\u00e9ine 1 (prot\u00e9ine anticoagulante naturelle) sur les phospholipides membranaires \u2192 inversion de la protection anticoagulante \u2192 activation de la coagulation + thrombus. La forme catastrophique du SAPL (CAPS \u2014 Catastrophic Antiphospholipid Syndrome) \u2014 heureusement rare (<1 % des SAPL) \u2014 est une urgence m\u00e9dicale mena\u00e7ant le pronostic vital avec des thromboses multiples et simultan\u00e9es touchant au moins 3 organes en moins d'une semaine, entra\u00eenant une d\u00e9faillance multivisc\u00e9rale et une mortalit\u00e9 de 30 \u00e0 50 % m\u00eame avec un traitement maximal.\n <\/div>\n\n <h2>Crit\u00e8res de classification \u2014 Sapporo r\u00e9vis\u00e9s (Sydney 2006)<\/h2>\n <ul class=\"co-list\">\n <li><strong>Le diagnostic de SAPL requiert \u2265 1 crit\u00e8re clinique ET \u2265 1 crit\u00e8re biologique :<\/strong><\/li>\n <li><strong>Crit\u00e8res cliniques :<\/strong> thrombose vasculaire (thrombose veineuse profonde + embolie pulmonaire + AVC + AIT + thrombose art\u00e9rielle p\u00e9riph\u00e9rique + ou thrombose de tout autre vaisseau) + ou morbidit\u00e9 obst\u00e9tricale (\u2265 1 mort f\u0153tale inexpliqu\u00e9e \u2265 10 semaines de grossesse avec morphologie f\u0153tale normale + ou \u2265 3 fausses couches spontan\u00e9es cons\u00e9cutives inexpliqu\u00e9es < 10 SA + ou \u2265 1 naissance pr\u00e9matur\u00e9e < 34 SA secondaire \u00e0 pr\u00e9-\u00e9clampsie s\u00e9v\u00e8re ou insuffisance placentaire s\u00e9v\u00e8re)<\/li>\n <li><strong>Crit\u00e8res biologiques (pr\u00e9sents \u00e0 \u2265 2 reprises \u00e0 \u2265 12 semaines d'intervalle) :<\/strong> anticoagulant lupique (AL) positif + ou aCL IgG ou IgM \u2265 40 GPL\/MPL (ou > 99e percentile) + ou anti-\u03b22GP1 IgG ou IgM > 99e percentile + la persistance sur 2 mesures \u00e0 12 semaines d'intervalle est obligatoire pour \u00e9viter de diagnostiquer des aPL transitoires (infections + m\u00e9dicaments) qui ne constituent pas un vrai SAPL<\/li>\n <li><strong>Profil \u00e0 risque \u00e9lev\u00e9 (triple positivit\u00e9) :<\/strong> Positivity of all 3 tests (lupus anticoagulant + anticardiolipin antibodies + anti-beta-2 glycoprotein 1 antibodies) = highest thrombotic risk + high risk of recurrence \u2192 lifelong anticoagulation often recommended<\/li>\n <\/ul>\n\n <h2>Clinical manifestations<\/h2>\n <ul class=\"co-list\">\n <li><strong>Venous thrombosis<\/strong> Deep vein thrombosis of the lower extremities ++ pulmonary embolism cerebral venous sinus thrombosis hepatic vein thrombosis (Budd-Chiari syndrome) renal vein thrombosis retinal vein thrombosis<\/li>\n <li><strong>Thromboses art\u00e9rielles :<\/strong> AVC isch\u00e9mique (particuli\u00e8rement chez la femme jeune < 50 ans sans facteur de risque classique \u2192 \u00e9voquer le SAPL) + AIT + infarctus du myocarde (chez le jeune) + occlusion art\u00e9rielle des membres + thrombose art\u00e9rielle r\u00e9tinienne (amaurose fugace + OAVR)<\/li>\n <li><strong>Manifestations obst\u00e9tricales :<\/strong> pertes f\u0153tales r\u00e9cidivantes (fausses couches spontan\u00e9es r\u00e9cidivantes + mort f\u0153tale in utero tardive) + pr\u00e9-\u00e9clampsie s\u00e9v\u00e8re pr\u00e9coce (< 34 SA) + syndrome HELLP + retard de croissance intra-ut\u00e9rin s\u00e9v\u00e8re + par m\u00e9canisme de thrombose des vaisseaux placentaires<\/li>\n <li><strong>Manifestations non crit\u00e8res (SAPL \u00e9volu\u00e9) :<\/strong> thrombocytopenia (20\u201350 % \u2014 platelets 50,000\u2013150,000\/\u00b5L) + valvular lesions (Libman-Sacks vegetations + valvular thickening + mitral or aortic insufficiency) + livedo reticularis (purplish skin network) + antiphospholipid nephropathy (renal thrombotic microangiopathy) + leg skin ulcers + refractory migraine<\/li>\n <\/ul>\n\n <h2>Catastrophic SAPL (CAPS)<\/h2>\n <ul class=\"co-list\">\n <li><strong>Definition:<\/strong> Multiple thromboses affecting three or more organs or vascular territories developing simultaneously or within less than a week, plus histology showing small vessel occlusions (thrombotic microangiopathy) and confirmed antiphospholipid antibodies.<\/li>\n <li><strong>Facteurs d\u00e9clenchants :<\/strong> infection bact\u00e9rienne (trigger le plus fr\u00e9quent \u2014 20 % des CAPS) + chirurgie + arr\u00eat brutal de l'anticoagulation + m\u00e9dicaments + grossesse<\/li>\n <li><strong>Manifestations:<\/strong> kidney failure (78 %) + lung damage (ARDS + 66 %) + brain damage (56 %) + heart damage (50 %) + severe thrombocytopenia + DIC + skin signs (livedo + necrosis)<\/li>\n <li><strong>Traitement (triple th\u00e9rapie) :<\/strong> IV anticoagulation (unfractionated heparin) + high-dose systemic corticosteroids (methylprednisolone 1 g\/day \u00d7 3 days then prednisone 1\u20132 mg\/kg\/day) + plasma exchange and\/or IV immunoglobulins \u2192 rituximab + eculizumab if refractory + 30\u201350% mortality % even with optimal treatment<\/li>\n <\/ul>\n\n <h2>Traitement \u2014 anticoagulation<\/h2>\n\n <table class=\"co-table\">\n <thead>\n <tr>\n <th>Situation<\/th>\n <th>Recommended treatment<\/th>\n <th>Dur\u00e9e et cibles<\/th>\n <\/tr>\n <\/thead>\n <tbody>\n <tr>\n <td>Premier \u00e9pisode thrombotique veineux + aPL confirm\u00e9<\/td>\n <td>Warfarine (Coumadin\u00ae) avec chevauchement h\u00e9parine jusqu'\u00e0 INR th\u00e9rapeutique + INR cible 2,0\u20133,0<\/td>\n <td>Anticoagulation \u00e0 vie si aPL persistants (les directives recommandent g\u00e9n\u00e9ralement l'anticoagulation \u00e0 vie apr\u00e8s le premier \u00e9pisode dans le contexte d'un SAPL confirm\u00e9) + profil triple positif \u2192 dur\u00e9e \u00e0 vie obligatoire<\/td>\n <\/tr>\n <tr>\n <td>Premier \u00e9pisode thrombotique art\u00e9riel (AVC + IDM)<\/td>\n <td>Warfarine INR cible 2,0\u20133,0 + ou INR 3,0\u20134,0 selon le profil aPL + aspirin 81\u2013100 mg\/j en combinaison (selon les lignes directrices)<\/td>\n <td>Anticoagulation \u00e0 vie + gestion rigoureuse des facteurs de risque cardiovasculaires (TA + lipides + tabac + diab\u00e8te)<\/td>\n <\/tr>\n <tr>\n <td>SAPL obst\u00e9trical (sans thrombose ant\u00e9rieure)<\/td>\n <td>H\u00e9parine de bas poids mol\u00e9culaire (HBPM \u2014 \u00e9noxaparine dose prophylactique 40 mg\/j SC) + aspirine faible dose (81 mg\/j) d\u00e8s la conception jusqu'\u00e0 l'accouchement + poursuite de l'HBPM 6 semaines post-partum<\/td>\n <td>Taux de naissances vivantes : 70\u201380 % sous traitement combin\u00e9 vs < 25 % sans traitement + HBPM \u00e0 dose th\u00e9rapeutique si ant\u00e9c\u00e9dent thrombotique associ\u00e9<\/td>\n <\/tr>\n <tr>\n <td>aPL positifs SANS crit\u00e8res cliniques (aPL asymptomatiques)<\/td>\n <td>Aspirine 81 mg\/j (prophylaxie primaire \u2014 controverse) + ou surveillance seule si profil aPL \u00e0 faible risque (aCL IgM isol\u00e9 \u00e0 faible titre) + hydroxychloroquine (lupus sous-jacent) \u2192 r\u00e9duit le risque de premi\u00e8re thrombose<\/td>\n <td>Facteurs de risque additionnels \u2192 aspirin + ou hydroxychloroquine + contr\u00f4le agressif des facteurs de risque cardiovasculaires classiques<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n\n <div class=\"co-infobox\">\n <span class=\"ico\">\u2119\ufe0f<\/span>\n <span>Les anticoagulants oraux directs (AOD \u2014 rivaroxaban + apixaban + dabigatran) ne sont PAS recommand\u00e9s dans le SAPL avec triple positivit\u00e9 ou ant\u00e9c\u00e9dent thrombotique art\u00e9riel \u2014 l'essai TRAPS (rivaroxaban vs warfarine dans le SAPL \u00e0 haut risque) a \u00e9t\u00e9 arr\u00eat\u00e9 pr\u00e9matur\u00e9ment en raison d'un taux de r\u00e9cidive thrombotique significativement plus \u00e9lev\u00e9 sous rivaroxaban. La warfarine reste le traitement de r\u00e9f\u00e9rence du SAPL thrombotique. Les AOD peuvent \u00eatre envisag\u00e9s uniquement dans les profils \u00e0 faible risque (aCL isol\u00e9 \u00e0 titre faible + premier \u00e9pisode veineux simple) en attendant des donn\u00e9es suppl\u00e9mentaires.<\/span>\n <\/div>\n\n <h2>SAPL et lupus \u2014 association importante<\/h2>\n <ul class=\"co-list\">\n <li><strong>Pr\u00e9valence :<\/strong> 30-40% of lupus patients have aPL+ and 50-70% of patients with secondary APS have lupus+ systematically screen for aPL in all lupus patients<\/li>\n <li><strong>Hydroxychloroquine (Plaquenil\u00ae) :<\/strong> Reduces the risk of thrombosis in lupus patients with aPL + mechanism: inhibition of platelet activation by aPL + anti-aggregating properties + immunomodulatory action \u2192 recommended for all lupus patients with positive aPL<\/li>\n <li><strong>Lupus pregnancy + APS:<\/strong> Highly specialized care at a reference center + LMWH + aspirin + hydroxychloroquine (safe in pregnancy) + prednisone if active lupus + close obstetric monitoring (bi-monthly placental Doppler ultrasound + fetal monitoring)<\/li>\n <\/ul>\n\n <div class=\"co-urgence\">\n <div class=\"co-urgence-titre\">Urgent medical consultation<\/div>\n <p>Consulter aux urgences imm\u00e9diatement si une personne connue pour SAPL pr\u00e9sente des signes de thrombose (douleur + gonflement d'un membre + dyspn\u00e9e + douleur thoracique + d\u00e9ficit neurologique) + ou si plusieurs organes semblent touch\u00e9s simultan\u00e9ment (confusion + oligurie + dyspn\u00e9e + douleur abdominale en m\u00eame temps) \u2014 ce dernier tableau peut \u00e9voquer un SAPL catastrophique, urgence m\u00e9dicale avec mortalit\u00e9 de 30\u201350 %. Pour le bilan initial des aPL (anticoagulant lupique + aCL + anti-\u03b22GP1) et l'orientation vers la rhumatologie ou l'h\u00e9matologie, Clinique Omicron offre des consultations dans ses points de service au Qu\u00e9bec et en t\u00e9l\u00e9m\u00e9decine. Pour prendre rendez-vous, visitez <a href=\"https:\/\/cliniqueomicron.ca\" style=\"color:#c0392b;font-weight:600;text-decoration:none;\">cliniqueomicron.ca<\/a>.<\/p>\n <\/div>\n\n <h2>Consult at Clinique Omicron<\/h2>\n <p>Les m\u00e9decins et infirmiers praticiens sp\u00e9cialis\u00e9s (IPS) de Clinique Omicron d\u00e9pistent le SAPL chez les patients pr\u00e9sentant des thromboses r\u00e9cidivantes inexpliqu\u00e9es + des fausses couches r\u00e9cidivantes + ou un AVC chez la femme jeune, prescrivent le bilan aPL complet (AL + aCL + anti-\u03b22GP1) avec r\u00e9p\u00e9tition \u00e0 12 semaines pour confirmer la persistance, initient l'aspirine en prophylaxie primaire et la warfarine en traitement des thromboses confirm\u00e9es, assurent le suivi de l'INR sous warfarine, orientent vers la rhumatologie pour le SAPL secondaire au lupus et vers l'obst\u00e9trique sp\u00e9cialis\u00e9e pour les grossesses \u00e0 risque. Des consultations sont disponibles dans plusieurs points de service au Qu\u00e9bec et en t\u00e9l\u00e9m\u00e9decine. Pour prendre rendez-vous, visitez <a href=\"https:\/\/cliniqueomicron.ca\" style=\"color:#4D6577;font-weight:600;text-decoration:none;\">cliniqueomicron.ca<\/a>.<\/p>\n\n <p class=\"co-disclaimer\">Le contenu de cette page est fourni \u00e0 titre informatif uniquement et ne remplace pas l'avis d'un m\u00e9decin, d'un rhumatologue ou d'un h\u00e9matologue. Le SAPL est une maladie complexe n\u00e9cessitant une anticoagulation \u00e0 long terme dont l'arr\u00eat brutal peut d\u00e9clencher un SAPL catastrophique. Les anticoagulants oraux directs (AOD) ne sont PAS recommand\u00e9s en premi\u00e8re intention dans le SAPL thrombotique \u2014 la warfarine reste le standard de soins.<\/p>\n\n<\/div>\n<\/body>\n<\/html>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron Rhumatologie & H\u00e9matologie & M\u00e9decine interne Syndrome des antiphospholipides (SAPL) Le syndrome des antiphospholipides (SAPL) \u2014 d\u00e9sign\u00e9 \u00e9galement syndrome de Hughes (du nom du rhumatologue britannique Graham Hughes qui l’a d\u00e9crit en 1983) \u2014 est une maladie auto-immune thrombophilique acquise caract\u00e9ris\u00e9e par la… <a href=\"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/\" rel=\"bookmark\">Read More \"<span class=\"screen-reader-text\">Antiphospholipid Syndrome (APS): Thrombosis, Pregnancy, and Treatment | Clinique Omicron<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_metasync_otto_title":"Syndrome des antiphospholipides | Brossard | Clinique Omicron","_metasync_otto_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","_metasync_otto_keywords":"","_metasync_otto_og_title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","_metasync_otto_og_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","_metasync_otto_twitter_title":"Syndrome Antiphospholipides | Clinique Omicron","_metasync_otto_twitter_description":"","rank_math_title":"","rank_math_description":"","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_aioseo_title":"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron","_aioseo_description":"Le SAPL est une thrombophilie auto-immune avec anticorps antiphospholipides. Crit\u00e8res Sapporo Sydney AL aCL anti-\u03b22GP1 persistance 12 semaines, warfarine INR 2-3 AOD contre-indiqu\u00e9s, HBPM aspirin grossesse, CAPS catastrophique au Qu\u00e9bec.","_metasync_seo_title":"Syndrome des antiphospholipides | Clinique Omicron","_metasync_seo_desc":"","_metasync_breadcrumb_title":"","_metasync_primary_category":0,"_metasync_primary_product_cat":0,"_metasync_imported_seo_title":"","_metasync_imported_seo_desc":"","_metasync_otto_disabled":"","_metasync_hreflang":"","_metasync_plugin_sync_ts":"{\"aioseo\":\"2026-09-03T07:54:20+00:00\"}","_metasync_robots_advanced":"","_metasync_og_title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","_metasync_og_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","_metasync_twitter_title":"Syndrome Antiphospholipides | Clinique Omicron","_metasync_twitter_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","footnotes":""},"class_list":["post-24978","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t<meta name=\"description\" content=\"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....\" \/>\n\t<meta name=\"robots\" content=\"max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n\t<meta name=\"google-site-verification\" content=\"yYDMZv-nme7Cg-KrW5GmEWceBTrCDv8zhSkkXdJSnyM\" \/>\n\t<meta name=\"msvalidate.01\" content=\"3225E6935FC4F40C7DDCE56C37141BA8\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinique Omicron - Clinique M\u00e9dicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec\" \/>\n\t\t<meta property=\"og:description\" content=\"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2026-03-01T02:54:43+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2026-09-14T23:52:47+00:00\" \/>\n\t\t<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/cliniqueomicron\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:site\" content=\"@CliniqueOmicron\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....\" \/>\n\t\t<meta name=\"twitter:creator\" content=\"@CliniqueOmicron\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en#listItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#listItem\",\"name\":\"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#listItem\",\"position\":2,\"name\":\"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en#listItem\",\"name\":\"Accueil\"}}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#webpage\",\"url\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/\",\"name\":\"Syndrome des antiphospholipides | Clinique Omicron\",\"description\":\"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\\u00e9dicale qui peut n\\u00e9cessiter une \\u00e9valuation et un suivi m\\u00e9dical appropri\\u00e9s....\",\"inLanguage\":\"en-CA\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/syndrome-antiphospholipides\\\/#breadcrumblist\"},\"datePublished\":\"2026-02-28T22:54:43-04:00\",\"dateModified\":\"2026-09-14T19:52:47-04:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/\",\"name\":\"Clinique Omicron\",\"description\":\"Clinique M\\u00e9dicale\",\"inLanguage\":\"en-CA\",\"publisher\":{\"@id\":\"https:\\\/\\\/cliniqueomicron.ca\\\/en\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t\r\n\t\t<title>Syndrome des antiphospholipides | Clinique Omicron<\/title>\n\n","aioseo_head_json":{"title":"Syndrome des antiphospholipides | Clinique Omicron","description":"Antiphospholipid Syndrome Antiphospholipid Syndrome is a medical condition that may require appropriate medical evaluation and monitoring....","canonical_url":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/","robots":"max-snippet:-1, max-image-preview:large, max-video-preview:-1","keywords":"","webmasterTools":{"google-site-verification":"yYDMZv-nme7Cg-KrW5GmEWceBTrCDv8zhSkkXdJSnyM","msvalidate.01":"3225E6935FC4F40C7DDCE56C37141BA8","miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BreadcrumbList","@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/cliniqueomicron.ca\/en#listItem","position":1,"name":"Accueil","item":"https:\/\/cliniqueomicron.ca\/en","nextItem":{"@type":"ListItem","@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#listItem","name":"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron"}},{"@type":"ListItem","@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#listItem","position":2,"name":"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron","previousItem":{"@type":"ListItem","@id":"https:\/\/cliniqueomicron.ca\/en#listItem","name":"Accueil"}}]},{"@type":"WebPage","@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#webpage","url":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/","name":"Syndrome des antiphospholipides | Clinique Omicron","description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","inLanguage":"en-CA","isPartOf":{"@id":"https:\/\/cliniqueomicron.ca\/en\/#website"},"breadcrumb":{"@id":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/#breadcrumblist"},"datePublished":"2026-02-28T22:54:43-04:00","dateModified":"2026-09-14T19:52:47-04:00"},{"@type":"WebSite","@id":"https:\/\/cliniqueomicron.ca\/en\/#website","url":"https:\/\/cliniqueomicron.ca\/en\/","name":"Clinique Omicron","description":"Clinique M\u00e9dicale","inLanguage":"en-CA","publisher":{"@id":"https:\/\/cliniqueomicron.ca\/en\/#organization"}}]},"og:locale":"en_US","og:site_name":"Clinique Omicron - Clinique M\u00e9dicale","og:type":"article","og:title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","og:description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","og:url":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/","og:image":"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg","og:image:secure_url":"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg","article:published_time":"2026-03-01T02:54:43+00:00","article:modified_time":"2026-09-14T23:52:47+00:00","article:publisher":"https:\/\/www.facebook.com\/cliniqueomicron","twitter:card":"summary_large_image","twitter:site":"@CliniqueOmicron","twitter:title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","twitter:description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","twitter:creator":"@CliniqueOmicron","twitter:image":"https:\/\/cliniqueomicron.ca\/wp-content\/uploads\/2025\/12\/unnamed-1-e1765579964732.jpg"},"aioseo_meta_data":{"post_id":"24978","title":"Syndrome des antiphospholipides | Clinique Omicron","description":"Antiphospholipid Syndrome Antiphospholipid Syndrome is a medical condition that may require appropriate medical evaluation and monitoring....","keywords":null,"keyphrases":{"focus":{"keyphrase":"antiphospholipides","score":75,"analysis":{"keyphraseInTitle":{"score":9,"maxScore":9,"error":0},"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":1},"keyphraseInURL":{"score":5,"maxScore":5,"error":0},"keyphraseInIntroduction":{"score":9,"maxScore":9,"error":0},"keyphraseInSubHeadings":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":[],"keywordDensity":{"type":"high","score":0,"maxScore":9,"error":1}}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":"Syndrome Antiphospholipides | Clinique Omicron Qu\u00e9bec","og_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":true,"twitter_card":"summary_large_image","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":"Syndrome Antiphospholipides | Clinique Omicron","twitter_description":"Syndrome des antiphospholipides Syndrome des antiphospholipides est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s....","schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"WebPage","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":false,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"large","priority":null,"frequency":"default","local_seo":null,"seo_analyzer_scan_date":"2026-09-15 00:05:17","breadcrumb_settings":null,"limit_modified_date":false,"reviewed_by":null,"open_ai":null,"ai":{"faqs":[],"keyPoints":[],"titles":[],"descriptions":[],"socialPosts":{"email":[],"linkedin":[],"twitter":[],"facebook":[],"instagram":[]}},"created":"2026-03-01 04:10:15","updated":"2026-09-15 00:22:17","focus_keyword":"antiphospholipides","additional_keywords":null,"truseo_locale":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t<a href=\"https:\/\/cliniqueomicron.ca\/en\" title=\"Accueil\">Accueil<\/a>\n<\/span><span class=\"aioseo-breadcrumb-separator\">\u203a<\/span><span class=\"aioseo-breadcrumb\">\n\tSyndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron\n<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Accueil","link":"https:\/\/cliniqueomicron.ca\/en"},{"label":"Syndrome des antiphospholipides (SAPL) : thromboses, grossesse et traitement | Clinique Omicron","link":"https:\/\/cliniqueomicron.ca\/en\/syndrome-antiphospholipides\/"}],"_links":{"self":[{"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/pages\/24978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/comments?post=24978"}],"version-history":[{"count":4,"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/pages\/24978\/revisions"}],"predecessor-version":[{"id":31836,"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/pages\/24978\/revisions\/31836"}],"wp:attachment":[{"href":"https:\/\/cliniqueomicron.ca\/en\/wp-json\/wp\/v2\/media?parent=24978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}