Xanthoma: Cutaneous Lipid Deposits, Diagnosis, and Associated Diseases | Clinique Omicron<\/title>\n<meta name=\"description\" content=\"Les xanthomes sont des d\u00e9p\u00f4ts de lipides dans la peau et les tendons signant une dyslipid\u00e9mie s\u00e9v\u00e8re. Xanthome tendineux hypercholest\u00e9rol\u00e9mie familiale, xanth\u00e9lasma, xanthome \u00e9ruptif triglyc\u00e9rides et bilan lipidique au Qu\u00e9bec.\">\n<meta name=\"keywords\" content=\"xanthome, xanth\u00e9lasma, xanthome tendineux, xanthome \u00e9ruptif, dyslipid\u00e9mie xanthome, hypercholest\u00e9rol\u00e9mie familiale xanthome, xanthome traitement, d\u00e9p\u00f4ts lipidiques peau, xanthome diagnostic, xanthome Qu\u00e9bec\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Cinzel:wght@600&family=Poppins:wght@400;500;600;700&display=swap\" rel=\"stylesheet\">\n<style>\n@import url('https:\/\/fonts.googleapis.com\/css2?family=Cinzel:wght@600&family=Poppins:wght@400;500;600;700&display=dump');\n\n.co-wrap * {\n font-family: 'Poppins', sans-serif;\n box-sizing: border-box;\n}\n.co-wrap {\n max-width: 1100px;\n margin: 0 auto;\n padding: 30px 0 60px;\n margin-top: 10px;\n}\n.co-label {\n font-family: 'Cinzel', serif;\n font-size: 14px;\n font-weight: bold;\n letter-spacing: 1px;\n text-transform: uppercase;\n color: #4D6577;\n margin-bottom: 14px;\n display: block;\n}\n.co-wrap h1 {\n font-size: 32px;\n font-weight: 500;\n color: #323C52;\n margin: 0 0 22px;\n line-height: 1.2;\n letter-spacing: 0.5px;\n}\n.co-intro {\n font-size: 16px;\n font-weight: 400;\n line-height: 1.75;\n color: #4D6577;\n margin-bottom: 36px;\n padding-bottom: 32px;\n border-bottom: 1px solid rgba(77,101,119,.2);\n}\n.co-wrap h2 {\n font-size: 20px;\n font-weight: 600;\n color: #323C52;\n margin: 32px 0 12px;\n letter-spacing: 0.3px;\n}\n.co-wrap p {\n font-size: 15px;\n font-weight: 400;\n color: #4D6577;\n line-height: 1.7;\n margin-bottom: 14px;\n}\n.co-list {\n list-style: none;\n padding: 0;\n margin: 12px 0 24px;\n}\n.co-list li {\n font-size: 15px;\n font-weight: 400;\n color: #4D6577;\n padding: 10px 14px 10px 38px;\n margin-bottom: 8px;\n border-radius: 6px;\n position: relative;\n background: rgba(77,101,119,.06);\n border-left: 3px solid #4D6577;\n}\n.co-list li::before {\n content: \"\u2713\";\n position: absolute;\n left: 12px;\n font-weight: 700;\n color: #4D6577;\n}\n.co-table {\n width: 100%;\n border-collapse: collapse;\n margin: 14px 0 22px;\n font-size: 14px;\n border-radius: 8px;\n overflow: hidden;\n}\n.co-table thead tr {\n background: #323C52;\n color: #fff;\n}\n.co-table thead th {\n padding: 11px 16px;\n text-align: left;\n font-weight: 600;\n font-size: 13px;\n}\n.co-table tbody tr:nth-child(even) {\n background: rgba(77,101,119,.06);\n}\n.co-table tbody tr:nth-child(odd) {\n background: #fff;\n}\n.co-table td {\n padding: 10px 16px;\n color: #4D6577;\n border-bottom: 1px solid rgba(77,101,119,.12);\n font-size: 14px;\n vertical-align: top;\n}\n.co-table td:first-child {\n font-weight: 600;\n color: #323C52;\n}\n.co-infobox {\n display: flex;\n gap: 12px;\n background: rgba(77,101,119,.06);\n border-radius: 8px;\n border-left: 4px solid #4D6577;\n padding: 14px 18px;\n margin: 18px 0 28px;\n font-size: 14px;\n font-weight: 400;\n color: #4D6577;\n line-height: 1.65;\n}\n.co-infobox .ico {\n font-size: 18px;\n flex-shrink: 0;\n}\n.co-urgence {\n background: #fff8f8;\n border-left: 5px solid #c0392b;\n border-radius: 6px;\n padding: 20px 26px;\n margin: 24px 0 32px;\n}\n.co-urgence .co-urgence-titre {\n font-size: 13px;\n font-weight: 700;\n color: #c0392b;\n letter-spacing: 1.5px;\n text-transform: uppercase;\n margin-bottom: 10px;\n}\n.co-urgence p {\n color: #5a2020;\n font-size: 14px;\n margin: 0 0 10px;\n line-height: 1.7;\n}\n.co-urgence p:last-child {\n margin-bottom: 0;\n}\n.co-disclaimer {\n font-size: 13px;\n color: #8a9aaa;\n font-style: italic;\n border-top: 1px solid rgba(77,101,119,.15);\n padding-top: 24px;\n margin-top: 40px;\n line-height: 1.6;\n}\n<\/style>\n<\/head>\n<body>\n<div class=\"co-wrap\">\n\n <span class=\"co-label\">Dermatologie & Cardiologie pr\u00e9ventive & M\u00e9decine de famille<\/span>\n <h1>Xanthomes (d\u00e9p\u00f4ts lipidiques)<\/h1>\n\n <div class=\"co-intro\">\n Les xanthomes sont des l\u00e9sions cutan\u00e9es et sous-cutan\u00e9es \u2014 parfois tendineuses \u2014 r\u00e9sultant de l'accumulation de lipides (principalement du cholest\u00e9rol est\u00e9rifi\u00e9 + des triglyc\u00e9rides + et des phospholipides) dans des macrophages spumeux (cellules spumeuses ou \u00abfoam cells\u00bb) au sein du derme + des tendons + ou d'autres tissus. Ils constituent des marqueurs cliniques pr\u00e9cieux de dyslipid\u00e9mies sous-jacentes \u2014 souvent s\u00e9v\u00e8res ou g\u00e9n\u00e9tiques \u2014 et repr\u00e9sentent un signal d'alarme cutan\u00e9 indiquant un risque cardiovasculaire significatif n\u00e9cessitant un bilan lipidique urgent. Les xanthomes ne sont pas une maladie en soi + mais le sympt\u00f4me visible d'une anomalie du m\u00e9tabolisme des lipoprot\u00e9ines circulantes + dont le traitement vise principalement la dyslipid\u00e9mie causale. Leur pr\u00e9sence peut pr\u00e9c\u00e9der de plusieurs ann\u00e9es la survenue d'\u00e9v\u00e9nements cardiovasculaires majeurs (infarctus du myocarde + accident vasculaire c\u00e9r\u00e9bral + maladie art\u00e9rielle p\u00e9riph\u00e9rique) + particuli\u00e8rement dans les formes g\u00e9n\u00e9tiques s\u00e9v\u00e8res comme l'hypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote (HF h\u00e9t\u00e9rozygote \u2014 la dyslipid\u00e9mie g\u00e9n\u00e9tique la plus fr\u00e9quente + touchant 1 personne sur 250 dans la population g\u00e9n\u00e9rale) ou homozygote (HF homozygote \u2014 extr\u00eamement s\u00e9v\u00e8re + 1 sur 300 000 + avec infarctus d\u00e8s l'enfance). La r\u00e9gression des xanthomes sous traitement hypolip\u00e9miant efficace est un marqueur indirect de la r\u00e9duction de la charge lipidique tissulaire + bien que leur disparition compl\u00e8te puisse prendre des ann\u00e9es m\u00eame apr\u00e8s normalisation des lipides sanguins.\n <\/div>\n\n <h2>Clinical classification of xanthomas<\/h2>\n\n <table class=\"co-table\">\n <thead>\n <tr>\n <th>Type of xanthoma<\/th>\n <th>Clinical aspect<\/th>\n <th>Typical location<\/th>\n <th>Dyslipid\u00e9mie associ\u00e9e<\/th>\n <\/tr>\n <\/thead>\n <tbody>\n <tr>\n <td>Tendon xanthoma<\/td>\n <td>Nodules fermes + indolores + mobiles sur le tendon lors des mouvements + couleur chair ou jaun\u00e2tre<\/td>\n <td>Tendon d'Achille +++ + tendons extenseurs des doigts + tendon rotulien + tendon tricipital<\/td>\n <td>Hypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote ou homozygote (LDL tr\u00e8s \u00e9lev\u00e9) + sitost\u00e9rol\u00e9mie + c\u00e9r\u00e9brotendineux xanthomatose (CTX)<\/td>\n <\/tr>\n <tr>\n <td>Xanth\u00e9lasma (xanthome plan palp\u00e9bral)<\/td>\n <td>Plaques jaun\u00e2tres + plates + l\u00e9g\u00e8rement sur\u00e9lev\u00e9es + molles + autour des paupi\u00e8res (coins internes)<\/td>\n <td>Paupi\u00e8res sup\u00e9rieures et inf\u00e9rieures \u2014 coins internes<\/td>\n <td>Hypercholest\u00e9rol\u00e9mie familiale + hyperlipid\u00e9mie combin\u00e9e + MAIS aussi 50 % des cas avec bilan lipidique NORMAL \u2192 bilan lipidique obligatoire mais xanth\u00e9lasma ne signifie pas toujours dyslipid\u00e9mie s\u00e9v\u00e8re<\/td>\n <\/tr>\n <tr>\n <td>Xanthome \u00e9ruptif<\/td>\n <td>Papules jaun\u00e2tres + petites + multiples + apparition soudaine + avec halo \u00e9ryth\u00e9mateux + prurigineuses<\/td>\n <td>Fesses + \u00e9paules + face d'extension des membres + tronc<\/td>\n <td>Hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re (TG >10\u201315 mmol\/L) +++ \u2192 hyperchylomicron\u00e9mie (type I) + dysb\u00eatalipoprot\u00e9in\u00e9mie + hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re secondaire (diab\u00e8te non contr\u00f4l\u00e9 + alcool + hypothyro\u00efdie + m\u00e9dicaments) \u2192 risque de pancr\u00e9atite aigu\u00eb +++<\/td>\n <\/tr>\n <tr>\n <td>Xanthome plan (non palp\u00e9bral)<\/td>\n <td>Plaques plates + jaun\u00e2tres + stri\u00e9es + dans les plis cutan\u00e9s<\/td>\n <td>Plis palmaires (xanthome stri\u00e9 palmar \u2014 pathognomonique de la dysb\u00eatalipoprot\u00e9in\u00e9mie = type III) + plis interfessiers + cou<\/td>\n <td>Dysb\u00eatalipoprot\u00e9in\u00e9mie (type III \u2014 \u00e9l\u00e9vation IDL + VLDL remnants + cholest\u00e9rol et TG \u00e9lev\u00e9s) + xanthome stri\u00e9 palmar = pathognomonique<\/td>\n <\/tr>\n <tr>\n <td>Xanthome tub\u00e9reux et tub\u00e9ro-\u00e9ruptif<\/td>\n <td>Nodules jaun\u00e2tres fermes + coalescents + parfois volumineux<\/td>\n <td>Elbows + knees + buttocks<\/td>\n <td>Hypercholest\u00e9rol\u00e9mie familiale homozygote +++ + dysb\u00eatalipoprot\u00e9in\u00e9mie<\/td>\n <\/tr>\n <tr>\n <td>Arc corn\u00e9en lipidique (g\u00e9rontoxon)<\/td>\n <td>Anneau blanc-gris\u00e2tre opaque en p\u00e9riph\u00e9rie de la corn\u00e9e (limbe) + ne g\u00eane pas la vision<\/td>\n <td>Corn\u00e9e \u2014 anneau p\u00e9riph\u00e9rique<\/td>\n <td>Chez l'adulte <45 ans \u2192 signe d'hypercholest\u00e9rol\u00e9mie familiale + risque cardiovasculaire \u00e9lev\u00e9 \u2192 bilan lipidique urgent + Chez l'adulte >60 ans \u2192 souvent physiologique (g\u00e9rontoxon)<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n\n <h2>Xanthome tendineux et hypercholest\u00e9rol\u00e9mie familiale<\/h2>\n <ul class=\"co-list\">\n <li><strong>Hypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote (HF h\u00e9t\u00e9ro) :<\/strong> mutation du g\u00e8ne LDLR (r\u00e9cepteur LDL) + APOB + ou PCSK9 \u2192 LDL-C tr\u00e8s \u00e9lev\u00e9 d\u00e8s la naissance (4\u20136 mmol\/L + parfois jusqu'\u00e0 8 mmol\/L) + sans traitement \u2192 infarctus \u00e0 40\u201350 ans chez l'homme + 50\u201360 ans chez la femme \u2192 xanthomes tendineux dans 20\u201330 % \u2192 traitement : statines haute intensit\u00e9 (rosuvastatine 40 mg + ou atorvastatine 80 mg) + \u00e9z\u00e9timibe + inhibiteurs PCSK9 (\u00e9volocumab + alirocumab) si LDL insuffisamment contr\u00f4l\u00e9 \u2192 objectif LDL <1,8 mmol\/L (ou <1,4 mmol\/L si haut risque)<\/li>\n <li><strong>Hypercholest\u00e9rol\u00e9mie familiale homozygote (HF homo) :<\/strong> Biallelic mutation \u2192 extreme LDL-C (10-30 mmol\/L) \u2192 massive tendinous xanthomas from childhood + early corneal arcus + infarction before 20 years old without treatment \u2192 treatment: statins + ezetimibe + PCSK9 inhibitors + lomitapide (MTP inhibitor) + inclisiran (anti-PCSK9 siRNA) + LDL apheresis (weekly extracorporeal clearance)<\/li>\n <li><strong>Dutch Lipid Clinic Network (DLCN) score:<\/strong> Clinical screening tool for FH \u2192 Family history + LDL-C + tendon xanthomas + corneal arcus + early CV history \u2192 score \u2265 8 = definite FH + 6\u20137 = probable + 3\u20135 = possible<\/li>\n <\/ul>\n\n <h2>Xanthome \u00e9ruptif et hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re<\/h2>\n <ul class=\"co-list\">\n <li><strong>Urgence m\u00e9tabolique :<\/strong> xanthomes \u00e9ruptifs + TG >10\u201315 mmol\/L \u2192 risque imminent de pancr\u00e9atite aigu\u00eb s\u00e9v\u00e8re \u2192 traitement urgent + hospitalisation si pancr\u00e9atite<\/li>\n <li><strong>Traitement de l'hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re :<\/strong> Very low-fat diet + cessation of alcohol + correction of secondary causes (diabetes + hypothyroidism + medications) + fibrates (fenofibrate\u2014first-line) + omega-3 fatty acids (Vascepa\u00ae Epanova EPA 4 g\/day if residual TG on statin)<\/li>\n <li><strong>R\u00e9gression des xanthomes \u00e9ruptifs :<\/strong> rapid (weeks to months) after triglyceride normalization \u2192 unlike tendinous xanthomas which can take years to regress<\/li>\n <\/ul>\n\n <div class=\"co-infobox\">\n <span class=\"ico\">\u2119\ufe0f<\/span>\n <span>Le xanthome stri\u00e9 palmar \u2014 d\u00e9p\u00f4ts lipidiques jaun\u00e2tres dans les plis des paumes des mains et des doigts \u2014 est un signe pathognomonique de la dysb\u00eatalipoprot\u00e9in\u00e9mie (hyperlipoprot\u00e9in\u00e9mie de type III \u2014 \u00e9l\u00e9vation simultan\u00e9e du cholest\u00e9rol et des triglyc\u00e9rides par accumulation des remnants IDL et VLDL). Ce signe, rare mais tr\u00e8s sp\u00e9cifique, doit imm\u00e9diatement d\u00e9clencher une \u00e9lectrophor\u00e8se des lipoprot\u00e9ines + un dosage de l'apolipoprot\u00e9ine E (g\u00e9notype ApoE \u03b52\/\u03b52 dans 90 % des cas) + et un traitement par fibrates ou statines. La dysb\u00eatalipoprot\u00e9in\u00e9mie est associ\u00e9e \u00e0 un risque cardiovasculaire et d'ath\u00e9roscl\u00e9rose p\u00e9riph\u00e9rique tr\u00e8s \u00e9lev\u00e9.<\/span>\n <\/div>\n\n <div class=\"co-urgence\">\n <div class=\"co-urgence-titre\">Medical consultation recommended<\/div>\n <p>Consulter un m\u00e9decin rapidement si des papules jaun\u00e2tres multiples apparaissent soudainement sur les fesses + les \u00e9paules + ou les membres (xanthomes \u00e9ruptifs) \u2014 ce signe peut indiquer une hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re avec risque imminent de pancr\u00e9atite aigu\u00eb. Consulter un m\u00e9decin si des nodules fermes sont palp\u00e9s sur les tendons d'Achille ou les extenseurs des doigts \u2014 un bilan lipidique complet incluant la recherche d'une hypercholest\u00e9rol\u00e9mie familiale est indispensable. Pour le bilan lipidique + le d\u00e9pistage de l'hypercholest\u00e9rol\u00e9mie familiale + et la prescription du traitement hypolip\u00e9miant, Clinique Omicron offre des consultations dans ses points de service au Qu\u00e9bec et en t\u00e9l\u00e9m\u00e9decine. Pour prendre rendez-vous, visitez <a href=\"https:\/\/cliniqueomicron.ca\" style=\"color:#c0392b;font-weight:600;text-decoration:none;\">cliniqueomicron.ca<\/a>.<\/p>\n <\/div>\n\n <h2>Consult at Clinique Omicron<\/h2>\n <p>Les m\u00e9decins et infirmiers praticiens sp\u00e9cialis\u00e9s (IPS) de Clinique Omicron reconnaissent les diff\u00e9rents types de xanthomes \u00e0 l'examen clinique (tendineux + \u00e9ruptifs + plan palmar + xanth\u00e9lasma), prescrivent un bilan lipidique complet avec calcul du score DLCN pour le d\u00e9pistage de l'hypercholest\u00e9rol\u00e9mie familiale, initient le traitement hypolip\u00e9miant adapt\u00e9 (statines haute intensit\u00e9 + \u00e9z\u00e9timibe + fibrates selon le type de dyslipid\u00e9mie), traitent en urgence les hypertriglyc\u00e9rid\u00e9mies s\u00e9v\u00e8res avec xanthomes \u00e9ruptifs, et orientent vers la cardiologie ou la g\u00e9n\u00e9tique m\u00e9dicale pour les hypercholest\u00e9rol\u00e9mies familiales s\u00e9v\u00e8res. Des consultations sont disponibles dans plusieurs points de service au Qu\u00e9bec et en t\u00e9l\u00e9m\u00e9decine. Pour prendre rendez-vous, visitez <a href=\"https:\/\/cliniqueomicron.ca\" style=\"color:#4D6577;font-weight:600;text-decoration:none;\">cliniqueomicron.ca<\/a>.<\/p>\n\n <p class=\"co-disclaimer\">Le contenu de cette page est fourni \u00e0 titre informatif uniquement et ne remplace pas l'avis d'un m\u00e9decin ou d'un cardiologue pr\u00e9ventif. Le xanth\u00e9lasma peut \u00eatre pr\u00e9sent avec un bilan lipidique normal \u2014 un bilan complet est n\u00e9cessaire mais son absence n'exclut pas la l\u00e9sion. Le xanthome \u00e9ruptif avec hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re constitue une urgence m\u00e9tabolique en raison du risque de pancr\u00e9atite aigu\u00eb.<\/p>\n\n<\/div>\n<\/body>\n<\/html>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Xanthome : d\u00e9p\u00f4ts lipidiques cutan\u00e9s, diagnostic et maladies associ\u00e9es | Clinique Omicron Dermatologie & Cardiologie pr\u00e9ventive & M\u00e9decine de famille Xanthomes (d\u00e9p\u00f4ts lipidiques) Les xanthomes sont des l\u00e9sions cutan\u00e9es et sous-cutan\u00e9es \u2014 parfois tendineuses \u2014 r\u00e9sultant de l’accumulation de lipides (principalement du cholest\u00e9rol est\u00e9rifi\u00e9 + des triglyc\u00e9rides + et des phospholipides) dans des macrophages spumeux… <a href=\"https:\/\/cliniqueomicron.ca\/en\/xanthome\/\" rel=\"bookmark\">Read More \"<span class=\"screen-reader-text\">Xanthoma: Cutaneous Lipid Deposits, Diagnosis, and Associated Diseases | Clinique Omicron<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_metasync_otto_title":"Xanthome (d\u00e9p\u00f4ts lipidiques) | Brossard | Clinique Omicron","_metasync_otto_description":"Xanthome (d\u00e9p\u00f4ts lipidiques) Xanthome (d\u00e9p\u00f4ts lipidiques) est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s. Nos p...","_metasync_otto_keywords":"xanthome, Clinique Omicron, clinique m\u00e9dicale Qu\u00e9bec, m\u00e9decin g\u00e9n\u00e9raliste Montr\u00e9al, Qu\u00e9bec","_metasync_otto_og_title":"","_metasync_otto_og_description":"Xanthome (d\u00e9p\u00f4ts lipidiques) Xanthome (d\u00e9p\u00f4ts lipidiques) est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s. Nos p...","_metasync_otto_twitter_title":"","_metasync_otto_twitter_description":"Xanthome (d\u00e9p\u00f4ts lipidiques) Xanthome (d\u00e9p\u00f4ts lipidiques) est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s. 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\n\t\t\t\t\t\n\n\n\n\nXanthoma: Cutaneous Lipid Deposits, Diagnosis, and Associated Diseases | Clinique Omicron<\/title>\n<meta name=\"description\" content=\"Les xanthomes sont des d\u00e9p\u00f4ts de lipides dans la peau et les tendons signant une dyslipid\u00e9mie s\u00e9v\u00e8re. Xanthome tendineux hypercholest\u00e9rol\u00e9mie familiale, xanth\u00e9lasma, xanthome \u00e9ruptif triglyc\u00e9rides et bilan lipidique au Qu\u00e9bec.\">\n<meta name=\"keywords\" content=\"xanthome, xanth\u00e9lasma, xanthome tendineux, xanthome \u00e9ruptif, dyslipid\u00e9mie xanthome, hypercholest\u00e9rol\u00e9mie familiale xanthome, xanthome traitement, d\u00e9p\u00f4ts lipidiques peau, xanthome diagnostic, xanthome Qu\u00e9bec\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Cinzel:wght@600&family=Poppins:wght@400;500;600;700&display=swap\" rel=\"stylesheet\">\n<style>\n@import url('https:\/\/fonts.googleapis.com\/css2?family=Cinzel:wght@600&family=Poppins:wght@400;500;600;700&display=dump');\n\n.co-wrap * {\n font-family: 'Poppins', sans-serif;\n box-sizing: border-box;\n}\n.co-wrap {\n max-width: 1100px;\n margin: 0 auto;\n padding: 30px 0 60px;\n margin-top: 10px;\n}\n.co-label {\n font-family: 'Cinzel', serif;\n font-size: 14px;\n font-weight: bold;\n letter-spacing: 1px;\n text-transform: uppercase;\n color: #4D6577;\n margin-bottom: 14px;\n display: block;\n}\n.co-wrap h1 {\n font-size: 32px;\n font-weight: 500;\n color: #323C52;\n margin: 0 0 22px;\n line-height: 1.2;\n letter-spacing: 0.5px;\n}\n.co-intro {\n font-size: 16px;\n font-weight: 400;\n line-height: 1.75;\n color: #4D6577;\n margin-bottom: 36px;\n padding-bottom: 32px;\n border-bottom: 1px solid rgba(77,101,119,.2);\n}\n.co-wrap h2 {\n font-size: 20px;\n font-weight: 600;\n color: #323C52;\n margin: 32px 0 12px;\n letter-spacing: 0.3px;\n}\n.co-wrap p {\n font-size: 15px;\n font-weight: 400;\n color: #4D6577;\n line-height: 1.7;\n margin-bottom: 14px;\n}\n.co-list {\n list-style: none;\n padding: 0;\n margin: 12px 0 24px;\n}\n.co-list li {\n font-size: 15px;\n font-weight: 400;\n color: #4D6577;\n padding: 10px 14px 10px 38px;\n margin-bottom: 8px;\n border-radius: 6px;\n position: relative;\n background: rgba(77,101,119,.06);\n border-left: 3px solid #4D6577;\n}\n.co-list li::before {\n content: \"\u2713\";\n position: absolute;\n left: 12px;\n font-weight: 700;\n color: #4D6577;\n}\n.co-table {\n width: 100%;\n border-collapse: collapse;\n margin: 14px 0 22px;\n font-size: 14px;\n border-radius: 8px;\n overflow: hidden;\n}\n.co-table thead tr {\n background: #323C52;\n color: #fff;\n}\n.co-table thead th {\n padding: 11px 16px;\n text-align: left;\n font-weight: 600;\n font-size: 13px;\n}\n.co-table tbody tr:nth-child(even) {\n background: rgba(77,101,119,.06);\n}\n.co-table tbody tr:nth-child(odd) {\n background: #fff;\n}\n.co-table td {\n padding: 10px 16px;\n color: #4D6577;\n border-bottom: 1px solid rgba(77,101,119,.12);\n font-size: 14px;\n vertical-align: top;\n}\n.co-table td:first-child {\n font-weight: 600;\n color: #323C52;\n}\n.co-infobox {\n display: flex;\n gap: 12px;\n background: rgba(77,101,119,.06);\n border-radius: 8px;\n border-left: 4px solid #4D6577;\n padding: 14px 18px;\n margin: 18px 0 28px;\n font-size: 14px;\n font-weight: 400;\n color: #4D6577;\n line-height: 1.65;\n}\n.co-infobox .ico {\n font-size: 18px;\n flex-shrink: 0;\n}\n.co-urgence {\n background: #fff8f8;\n border-left: 5px solid #c0392b;\n border-radius: 6px;\n padding: 20px 26px;\n margin: 24px 0 32px;\n}\n.co-urgence .co-urgence-titre {\n font-size: 13px;\n font-weight: 700;\n color: #c0392b;\n letter-spacing: 1.5px;\n text-transform: uppercase;\n margin-bottom: 10px;\n}\n.co-urgence p {\n color: #5a2020;\n font-size: 14px;\n margin: 0 0 10px;\n line-height: 1.7;\n}\n.co-urgence p:last-child {\n margin-bottom: 0;\n}\n.co-disclaimer {\n font-size: 13px;\n color: #8a9aaa;\n font-style: italic;\n border-top: 1px solid rgba(77,101,119,.15);\n padding-top: 24px;\n margin-top: 40px;\n line-height: 1.6;\n}\n<\/style>\n<\/head>\n<body>\n<div class=\"co-wrap\">\n\n <span class=\"co-label\">Dermatologie & Cardiologie pr\u00e9ventive & M\u00e9decine de famille<\/span>\n <h1>Xanthomes (d\u00e9p\u00f4ts lipidiques)<\/h1>\n\n <div class=\"co-intro\">\n Les xanthomes sont des l\u00e9sions cutan\u00e9es et sous-cutan\u00e9es \u2014 parfois tendineuses \u2014 r\u00e9sultant de l'accumulation de lipides (principalement du cholest\u00e9rol est\u00e9rifi\u00e9 + des triglyc\u00e9rides + et des phospholipides) dans des macrophages spumeux (cellules spumeuses ou \u00abfoam cells\u00bb) au sein du derme + des tendons + ou d'autres tissus. Ils constituent des marqueurs cliniques pr\u00e9cieux de dyslipid\u00e9mies sous-jacentes \u2014 souvent s\u00e9v\u00e8res ou g\u00e9n\u00e9tiques \u2014 et repr\u00e9sentent un signal d'alarme cutan\u00e9 indiquant un risque cardiovasculaire significatif n\u00e9cessitant un bilan lipidique urgent. Les xanthomes ne sont pas une maladie en soi + mais le sympt\u00f4me visible d'une anomalie du m\u00e9tabolisme des lipoprot\u00e9ines circulantes + dont le traitement vise principalement la dyslipid\u00e9mie causale. Leur pr\u00e9sence peut pr\u00e9c\u00e9der de plusieurs ann\u00e9es la survenue d'\u00e9v\u00e9nements cardiovasculaires majeurs (infarctus du myocarde + accident vasculaire c\u00e9r\u00e9bral + maladie art\u00e9rielle p\u00e9riph\u00e9rique) + particuli\u00e8rement dans les formes g\u00e9n\u00e9tiques s\u00e9v\u00e8res comme l'hypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote (HF h\u00e9t\u00e9rozygote \u2014 la dyslipid\u00e9mie g\u00e9n\u00e9tique la plus fr\u00e9quente + touchant 1 personne sur 250 dans la population g\u00e9n\u00e9rale) ou homozygote (HF homozygote \u2014 extr\u00eamement s\u00e9v\u00e8re + 1 sur 300 000 + avec infarctus d\u00e8s l'enfance). La r\u00e9gression des xanthomes sous traitement hypolip\u00e9miant efficace est un marqueur indirect de la r\u00e9duction de la charge lipidique tissulaire + bien que leur disparition compl\u00e8te puisse prendre des ann\u00e9es m\u00eame apr\u00e8s normalisation des lipides sanguins.\n <\/div>\n\n <h2>Clinical classification of xanthomas<\/h2>\n\n <table class=\"co-table\">\n <thead>\n <tr>\n <th>Type of xanthoma<\/th>\n <th>Clinical aspect<\/th>\n <th>Typical location<\/th>\n <th>Dyslipid\u00e9mie associ\u00e9e<\/th>\n <\/tr>\n <\/thead>\n <tbody>\n <tr>\n <td>Tendon xanthoma<\/td>\n <td>Nodules fermes + indolores + mobiles sur le tendon lors des mouvements + couleur chair ou jaun\u00e2tre<\/td>\n <td>Tendon d'Achille +++ + tendons extenseurs des doigts + tendon rotulien + tendon tricipital<\/td>\n <td>Hypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote ou homozygote (LDL tr\u00e8s \u00e9lev\u00e9) + sitost\u00e9rol\u00e9mie + c\u00e9r\u00e9brotendineux xanthomatose (CTX)<\/td>\n <\/tr>\n <tr>\n <td>Xanth\u00e9lasma (xanthome plan palp\u00e9bral)<\/td>\n <td>Plaques jaun\u00e2tres + plates + l\u00e9g\u00e8rement sur\u00e9lev\u00e9es + molles + autour des paupi\u00e8res (coins internes)<\/td>\n <td>Paupi\u00e8res sup\u00e9rieures et inf\u00e9rieures \u2014 coins internes<\/td>\n <td>Hypercholest\u00e9rol\u00e9mie familiale + hyperlipid\u00e9mie combin\u00e9e + MAIS aussi 50 % des cas avec bilan lipidique NORMAL \u2192 bilan lipidique obligatoire mais xanth\u00e9lasma ne signifie pas toujours dyslipid\u00e9mie s\u00e9v\u00e8re<\/td>\n <\/tr>\n <tr>\n <td>Xanthome \u00e9ruptif<\/td>\n <td>Papules jaun\u00e2tres + petites + multiples + apparition soudaine + avec halo \u00e9ryth\u00e9mateux + prurigineuses<\/td>\n <td>Fesses + \u00e9paules + face d'extension des membres + tronc<\/td>\n <td>Hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re (TG >10\u201315 mmol\/L) +++ \u2192 hyperchylomicron\u00e9mie (type I) + dysb\u00eatalipoprot\u00e9in\u00e9mie + hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re secondaire (diab\u00e8te non contr\u00f4l\u00e9 + alcool + hypothyro\u00efdie + m\u00e9dicaments) \u2192 risque de pancr\u00e9atite aigu\u00eb +++<\/td>\n <\/tr>\n <tr>\n <td>Xanthome plan (non palp\u00e9bral)<\/td>\n <td>Plaques plates + jaun\u00e2tres + stri\u00e9es + dans les plis cutan\u00e9s<\/td>\n <td>Plis palmaires (xanthome stri\u00e9 palmar \u2014 pathognomonique de la dysb\u00eatalipoprot\u00e9in\u00e9mie = type III) + plis interfessiers + cou<\/td>\n <td>Dysb\u00eatalipoprot\u00e9in\u00e9mie (type III \u2014 \u00e9l\u00e9vation IDL + VLDL remnants + cholest\u00e9rol et TG \u00e9lev\u00e9s) + xanthome stri\u00e9 palmar = pathognomonique<\/td>\n <\/tr>\n <tr>\n <td>Xanthome tub\u00e9reux et tub\u00e9ro-\u00e9ruptif<\/td>\n <td>Nodules jaun\u00e2tres fermes + coalescents + parfois volumineux<\/td>\n <td>Elbows + knees + buttocks<\/td>\n <td>Hypercholest\u00e9rol\u00e9mie familiale homozygote +++ + dysb\u00eatalipoprot\u00e9in\u00e9mie<\/td>\n <\/tr>\n <tr>\n <td>Arc corn\u00e9en lipidique (g\u00e9rontoxon)<\/td>\n <td>Anneau blanc-gris\u00e2tre opaque en p\u00e9riph\u00e9rie de la corn\u00e9e (limbe) + ne g\u00eane pas la vision<\/td>\n <td>Corn\u00e9e \u2014 anneau p\u00e9riph\u00e9rique<\/td>\n <td>Chez l'adulte <45 ans \u2192 signe d'hypercholest\u00e9rol\u00e9mie familiale + risque cardiovasculaire \u00e9lev\u00e9 \u2192 bilan lipidique urgent + Chez l'adulte >60 ans \u2192 souvent physiologique (g\u00e9rontoxon)<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n\n <h2>Xanthome tendineux et hypercholest\u00e9rol\u00e9mie familiale<\/h2>\n <ul class=\"co-list\">\n <li><strong>Hypercholest\u00e9rol\u00e9mie familiale h\u00e9t\u00e9rozygote (HF h\u00e9t\u00e9ro) :<\/strong> mutation du g\u00e8ne LDLR (r\u00e9cepteur LDL) + APOB + ou PCSK9 \u2192 LDL-C tr\u00e8s \u00e9lev\u00e9 d\u00e8s la naissance (4\u20136 mmol\/L + parfois jusqu'\u00e0 8 mmol\/L) + sans traitement \u2192 infarctus \u00e0 40\u201350 ans chez l'homme + 50\u201360 ans chez la femme \u2192 xanthomes tendineux dans 20\u201330 % \u2192 traitement : statines haute intensit\u00e9 (rosuvastatine 40 mg + ou atorvastatine 80 mg) + \u00e9z\u00e9timibe + inhibiteurs PCSK9 (\u00e9volocumab + alirocumab) si LDL insuffisamment contr\u00f4l\u00e9 \u2192 objectif LDL <1,8 mmol\/L (ou <1,4 mmol\/L si haut risque)<\/li>\n <li><strong>Hypercholest\u00e9rol\u00e9mie familiale homozygote (HF homo) :<\/strong> Biallelic mutation \u2192 extreme LDL-C (10-30 mmol\/L) \u2192 massive tendinous xanthomas from childhood + early corneal arcus + infarction before 20 years old without treatment \u2192 treatment: statins + ezetimibe + PCSK9 inhibitors + lomitapide (MTP inhibitor) + inclisiran (anti-PCSK9 siRNA) + LDL apheresis (weekly extracorporeal clearance)<\/li>\n <li><strong>Dutch Lipid Clinic Network (DLCN) score:<\/strong> Clinical screening tool for FH \u2192 Family history + LDL-C + tendon xanthomas + corneal arcus + early CV history \u2192 score \u2265 8 = definite FH + 6\u20137 = probable + 3\u20135 = possible<\/li>\n <\/ul>\n\n <h2>Xanthome \u00e9ruptif et hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re<\/h2>\n <ul class=\"co-list\">\n <li><strong>Urgence m\u00e9tabolique :<\/strong> xanthomes \u00e9ruptifs + TG >10\u201315 mmol\/L \u2192 risque imminent de pancr\u00e9atite aigu\u00eb s\u00e9v\u00e8re \u2192 traitement urgent + hospitalisation si pancr\u00e9atite<\/li>\n <li><strong>Traitement de l'hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re :<\/strong> Very low-fat diet + cessation of alcohol + correction of secondary causes (diabetes + hypothyroidism + medications) + fibrates (fenofibrate\u2014first-line) + omega-3 fatty acids (Vascepa\u00ae Epanova EPA 4 g\/day if residual TG on statin)<\/li>\n <li><strong>R\u00e9gression des xanthomes \u00e9ruptifs :<\/strong> rapid (weeks to months) after triglyceride normalization \u2192 unlike tendinous xanthomas which can take years to regress<\/li>\n <\/ul>\n\n <div class=\"co-infobox\">\n <span class=\"ico\">\u2119\ufe0f<\/span>\n <span>Le xanthome stri\u00e9 palmar \u2014 d\u00e9p\u00f4ts lipidiques jaun\u00e2tres dans les plis des paumes des mains et des doigts \u2014 est un signe pathognomonique de la dysb\u00eatalipoprot\u00e9in\u00e9mie (hyperlipoprot\u00e9in\u00e9mie de type III \u2014 \u00e9l\u00e9vation simultan\u00e9e du cholest\u00e9rol et des triglyc\u00e9rides par accumulation des remnants IDL et VLDL). Ce signe, rare mais tr\u00e8s sp\u00e9cifique, doit imm\u00e9diatement d\u00e9clencher une \u00e9lectrophor\u00e8se des lipoprot\u00e9ines + un dosage de l'apolipoprot\u00e9ine E (g\u00e9notype ApoE \u03b52\/\u03b52 dans 90 % des cas) + et un traitement par fibrates ou statines. La dysb\u00eatalipoprot\u00e9in\u00e9mie est associ\u00e9e \u00e0 un risque cardiovasculaire et d'ath\u00e9roscl\u00e9rose p\u00e9riph\u00e9rique tr\u00e8s \u00e9lev\u00e9.<\/span>\n <\/div>\n\n <div class=\"co-urgence\">\n <div class=\"co-urgence-titre\">Medical consultation recommended<\/div>\n <p>Consulter un m\u00e9decin rapidement si des papules jaun\u00e2tres multiples apparaissent soudainement sur les fesses + les \u00e9paules + ou les membres (xanthomes \u00e9ruptifs) \u2014 ce signe peut indiquer une hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re avec risque imminent de pancr\u00e9atite aigu\u00eb. Consulter un m\u00e9decin si des nodules fermes sont palp\u00e9s sur les tendons d'Achille ou les extenseurs des doigts \u2014 un bilan lipidique complet incluant la recherche d'une hypercholest\u00e9rol\u00e9mie familiale est indispensable. Pour le bilan lipidique + le d\u00e9pistage de l'hypercholest\u00e9rol\u00e9mie familiale + et la prescription du traitement hypolip\u00e9miant, Clinique Omicron offre des consultations dans ses points de service au Qu\u00e9bec et en t\u00e9l\u00e9m\u00e9decine. Pour prendre rendez-vous, visitez <a href=\"https:\/\/cliniqueomicron.ca\" style=\"color:#c0392b;font-weight:600;text-decoration:none;\">cliniqueomicron.ca<\/a>.<\/p>\n <\/div>\n\n <h2>Consult at Clinique Omicron<\/h2>\n <p>Les m\u00e9decins et infirmiers praticiens sp\u00e9cialis\u00e9s (IPS) de Clinique Omicron reconnaissent les diff\u00e9rents types de xanthomes \u00e0 l'examen clinique (tendineux + \u00e9ruptifs + plan palmar + xanth\u00e9lasma), prescrivent un bilan lipidique complet avec calcul du score DLCN pour le d\u00e9pistage de l'hypercholest\u00e9rol\u00e9mie familiale, initient le traitement hypolip\u00e9miant adapt\u00e9 (statines haute intensit\u00e9 + \u00e9z\u00e9timibe + fibrates selon le type de dyslipid\u00e9mie), traitent en urgence les hypertriglyc\u00e9rid\u00e9mies s\u00e9v\u00e8res avec xanthomes \u00e9ruptifs, et orientent vers la cardiologie ou la g\u00e9n\u00e9tique m\u00e9dicale pour les hypercholest\u00e9rol\u00e9mies familiales s\u00e9v\u00e8res. Des consultations sont disponibles dans plusieurs points de service au Qu\u00e9bec et en t\u00e9l\u00e9m\u00e9decine. Pour prendre rendez-vous, visitez <a href=\"https:\/\/cliniqueomicron.ca\" style=\"color:#4D6577;font-weight:600;text-decoration:none;\">cliniqueomicron.ca<\/a>.<\/p>\n\n <p class=\"co-disclaimer\">Le contenu de cette page est fourni \u00e0 titre informatif uniquement et ne remplace pas l'avis d'un m\u00e9decin ou d'un cardiologue pr\u00e9ventif. Le xanth\u00e9lasma peut \u00eatre pr\u00e9sent avec un bilan lipidique normal \u2014 un bilan complet est n\u00e9cessaire mais son absence n'exclut pas la l\u00e9sion. Le xanthome \u00e9ruptif avec hypertriglyc\u00e9rid\u00e9mie s\u00e9v\u00e8re constitue une urgence m\u00e9tabolique en raison du risque de pancr\u00e9atite aigu\u00eb.<\/p>\n\n<\/div>\n<\/body>\n<\/html>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Xanthome : d\u00e9p\u00f4ts lipidiques cutan\u00e9s, diagnostic et maladies associ\u00e9es | Clinique Omicron Dermatologie & Cardiologie pr\u00e9ventive & M\u00e9decine de famille Xanthomes (d\u00e9p\u00f4ts lipidiques) Les xanthomes sont des l\u00e9sions cutan\u00e9es et sous-cutan\u00e9es \u2014 parfois tendineuses \u2014 r\u00e9sultant de l’accumulation de lipides (principalement du cholest\u00e9rol est\u00e9rifi\u00e9 + des triglyc\u00e9rides + et des phospholipides) dans des macrophages spumeux… <a href=\"https:\/\/cliniqueomicron.ca\/en\/xanthome\/\" rel=\"bookmark\">Read More \"<span class=\"screen-reader-text\">Xanthoma: Cutaneous Lipid Deposits, Diagnosis, and Associated Diseases | Clinique Omicron<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_metasync_otto_title":"Xanthome (d\u00e9p\u00f4ts lipidiques) | Brossard | Clinique Omicron","_metasync_otto_description":"Xanthome (d\u00e9p\u00f4ts lipidiques) Xanthome (d\u00e9p\u00f4ts lipidiques) est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s. Nos p...","_metasync_otto_keywords":"xanthome, Clinique Omicron, clinique m\u00e9dicale Qu\u00e9bec, m\u00e9decin g\u00e9n\u00e9raliste Montr\u00e9al, Qu\u00e9bec","_metasync_otto_og_title":"","_metasync_otto_og_description":"Xanthome (d\u00e9p\u00f4ts lipidiques) Xanthome (d\u00e9p\u00f4ts lipidiques) est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s. Nos p...","_metasync_otto_twitter_title":"","_metasync_otto_twitter_description":"Xanthome (d\u00e9p\u00f4ts lipidiques) Xanthome (d\u00e9p\u00f4ts lipidiques) est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s. Nos p...","rank_math_title":"","rank_math_description":"","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_aioseo_title":"Xanthome : d\u00e9p\u00f4ts lipidiques cutan\u00e9s, diagnostic et maladies associ\u00e9es | Clinique Omicron","_aioseo_description":"Les xanthomes signalent une dyslipid\u00e9mie s\u00e9v\u00e8re. Xanthome tendineux Achille HF LDLR DLCN score, xanth\u00e9lasma paupi\u00e8res bilan lipidique, xanthome \u00e9ruptif TG >10-15 pancr\u00e9atite urgence, xanthome stri\u00e9 palmar dysb\u00eatalipoprot\u00e9in\u00e9mie type III au Qu\u00e9bec.","_metasync_seo_title":"","_metasync_seo_desc":"","_metasync_breadcrumb_title":"","_metasync_primary_category":0,"_metasync_primary_product_cat":0,"_metasync_otto_disabled":"","_metasync_hreflang":"","_metasync_plugin_sync_ts":"{\"aioseo\":\"2026-05-04T21:54:53+00:00\"}","_metasync_robots_advanced":"","footnotes":""},"class_list":["post-25073","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t<meta name=\"description\" content=\"Xanthome (d\u00e9p\u00f4ts lipidiques) Xanthome (d\u00e9p\u00f4ts lipidiques) est une condition m\u00e9dicale qui peut n\u00e9cessiter une \u00e9valuation et un suivi m\u00e9dical appropri\u00e9s. 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